Buxton A E, Highsmith A K, Garner J S, West C M, Stamm W E, Dixon R E, McGowan J E
Ann Intern Med. 1979 May;90(5):764-8. doi: 10.7326/0003-4819-90-5-764.
Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, in-use i.v. fluid contamination, and phlebitis in 300 patients whose administration sets were changed every 24 h with those in 300 patients whose administration sets were changed every 48 h. No i.v.-associated bacteremia occurred. Twelve of 600 infusions (2%) had positive infusion-fluid cultures: five in one group and seven in the other. Both groups had comparable rates of phlebitis. In this study population with low rates of fluid contamination, no benefit accrued from changing the administration sets every 24 h instead of every 48 h. In hospitals with low rates of fluid contamination, the routine changing of i.v. administration sets every 48 h will result in substantial financial savings.
自1973年以来，疾病控制中心一直建议每天更换静脉输液装置，以降低输液菌血症的风险。为评估这一建议，我们进行了一项前瞻性、随机对照试验，比较了300例输液装置每24小时更换一次的患者与300例输液装置每48小时更换一次的患者的静脉相关菌血症发生率、使用中的静脉输液污染率和静脉炎发生率。未发生静脉相关菌血症。600次输液中有12次（2%）输液液培养呈阳性：一组5次，另一组7次。两组静脉炎发生率相当。在这个输液污染率较低的研究人群中，每24小时而不是每48小时更换输液装置并没有带来益处。在输液污染率较低的医院，每48小时常规更换静脉输液装置将节省大量资金。
