银杏叶提取物负载淀粉纳米球的制备、表征及体外释放动力学研究。
Ginkgo biloba extracts-loaded starch nano-spheres: Preparation, characterization, and in vitro release kinetics.
机构信息
College of Light Industry Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province, 210037, China; Department of Chemistry Engineering, Xuzhou College of Industrial Technology, Xuzhou, Jiangsu Province, 221140, China.
College of Light Industry Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu Province, 210037, China; Co-Innovation Centre for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu Province, 210037, China.
出版信息
Int J Biol Macromol. 2018 Jan;106:148-157. doi: 10.1016/j.ijbiomac.2017.08.012. Epub 2017 Aug 3.
Ginkgo as a promising edible material and herbal medicine has received much attention due to its abundant starch contents and functional ingredient ginkgo biloba extracts (GBEs). Many foreign scholars suggest that GBEs can effectively ameliorate the symptoms of mild memory impairment and Alzheimer's dementia. However, an insurmountable problem with application of the GBEs is its low bioavailability, which restricts its application in vivo. Considering the biocompatibility between GBEs and starch, we have prepared ginkgo and corn starch-based nano-carriers, and thereby loaded GBEs onto starch nano-spheres (SNPs) by nanoprecipitation. Compared with unloaded SNPs (201-250nm), the mean sizes of the monodispersed and spherical GBEs-loaded SNPs were 255-396nm. Moreover, the loading amounts of GBEs onto ginkgo, and corn SNPs were 0.661-1.045, and 0.560mg/mg, respectively. In addition, in artificial gastric and intestinal juices, the GBEs-loaded SNPs exhibited a better sustained release than free GBEs.
银杏作为一种有前景的食用材料和草药，由于其丰富的淀粉含量和功能性成分银杏叶提取物（GBE），受到了广泛关注。许多国外学者认为GBE 可以有效改善轻度记忆障碍和阿尔茨海默病的症状。然而，GBE 在应用中存在一个不可逾越的问题，即生物利用度低，这限制了其在体内的应用。考虑到 GBE 与淀粉之间的生物相容性，我们已经制备了银杏和玉米淀粉基纳米载体，并通过纳米沉淀将 GBE 负载到淀粉纳米球（SNP）上。与未负载的 SNP（201-250nm）相比，单分散和球形 GBE 负载 SNP 的平均粒径为 255-396nm。此外，银杏和玉米 SNP 对 GBE 的载药量分别为 0.661-1.045mg/mg 和 0.560mg/mg。此外，在人工胃液和肠液中，负载 GBE 的 SNP 比游离 GBE 具有更好的缓释效果。
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