Platek Alexis J, Cannioto Rikki A, Etter John Lewis, Kim Jae, Joseph Janine M, Gulati Nicholas R, Schmitt Kristina L, Callahan Emily, Khachatryan Edgar, Nagy Ryan, Minlikeeva Albina, Brian Szender J, Singh Anurag K, Danziger Iris, Moysich Kirsten B
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, 352 Carlton House, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Department of Otolaryngology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, 1237 Delaware Avenue, Buffalo, NY, 14209, USA.
Eur Arch Otorhinolaryngol. 2017 Oct;274(10):3773-3780. doi: 10.1007/s00405-017-4688-3. Epub 2017 Aug 5.
Despite mounting epidemiological evidence suggesting an inverse association between recreational physical activity and cancer risk, evidence associated with head and neck cancer is scant. We conducted a case-control analysis to examine the associations of lifetime physical inactivity with the risk of head and neck squamous cell carcinoma (HNSCC). We utilized data from the Patient Epidemiology Data System at Roswell Park Cancer Institute (RPCI). Participants included 246 patients with HNSCC and 504 cancer-free controls who received medical services at RPCI between 1990 and 1998. Participants were considered physically inactive if they did not participate in any regular, weekly recreational physical activity throughout their lifetime, prior to diagnosis. Multivariate logistic regression models were utilized to estimate odds ratios (OR) and 95% confidence intervals (CI) representing the association between lifetime physical inactivity and HNSCC risk. We observed a significant positive association between recreational physical inactivity and HNSCC risk (OR = 2.73, 95% CI 1.87-3.99, p < 0.001). In subgroup analyses by body mass index (BMI) (underweight/normal-weight: OR = 3.40, 95% CI 1.89-6.12, p < 0.001; overweight/obese: OR = 2.40, 95% CI 1.43-4.02, p < 0.001) and smoking status (former smoker: OR = 3.12, 95% CI 1.89-5.14, p < 0.001; never smoker: OR = 2.71, 95% CI 1.21-6.05, p = 0.020; current smoker: OR = 1.61, 95% CI 0.66-3.95, p = 0.300), significant positive associations were also observed. Results of the current analyses suggest that lifetime physical inactivity associates with HNSCC independent of BMI. In addition, physical inactivity may be a modifiable risk factor among never smokers. These data add to the growing body of evidence suggesting that physical inactivity may be an independent risk factor for cancer.
尽管越来越多的流行病学证据表明休闲体育活动与癌症风险呈负相关，但与头颈癌相关的证据却很少。我们进行了一项病例对照分析，以研究终生缺乏体育活动与头颈鳞状细胞癌（HNSCC）风险之间的关联。我们利用了罗斯韦尔公园癌症研究所（RPCI）患者流行病学数据系统的数据。参与者包括246例HNSCC患者和504例无癌对照者，他们在1990年至1998年间在RPCI接受医疗服务。如果参与者在诊断前一生中从未参加过任何定期的每周休闲体育活动，则被视为缺乏体育活动。采用多变量逻辑回归模型来估计比值比（OR）和95%置信区间（CI），以表示终生缺乏体育活动与HNSCC风险之间的关联。我们观察到休闲体育活动缺乏与HNSCC风险之间存在显著的正相关（OR = 2.73，95% CI 1.87 - 3.99，p < 0.001）。在按体重指数（BMI）进行的亚组分析中（体重过轻/正常体重：OR = 3.40，95% CI 1.89 - 6.12，p < 0.001；超重/肥胖：OR = 2.40，95% CI 1.43 - 4.02，p < 0.001）以及吸烟状况（既往吸烟者：OR = 3.12，95% CI 1.89 - 5.14，p < 0.001；从不吸烟者：OR = 2.71，95% CI 1.21 - 6.05，p = 0.020；当前吸烟者：OR = 1.61，95% CI 0.66 - 3.95，p = 0.300），也观察到了显著的正相关。当前分析的结果表明，终生缺乏体育活动与HNSCC相关，且独立于BMI。此外，缺乏体育活动可能是从不吸烟者中一个可改变的风险因素。这些数据进一步增加了越来越多的证据，表明缺乏体育活动可能是癌症的一个独立风险因素。
