Cannioto Rikki, Etter John Lewis, Guterman Lauren Beryl, Joseph Janine M, Gulati Nicholas R, Schmitt Kristina L, LaMonte Michael J, Nagy Ryan, Minlikeeva Albina, Szender James Brian, Moysich Kirsten B
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, NY 14263, United States.
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA 30322, United States.
Cancer Epidemiol. 2017 Aug;49:24-29. doi: 10.1016/j.canep.2017.04.017. Epub 2017 May 18.
Recreational physical inactivity has been gaining recognition as an independent epidemiological exposure of interest in relation to cancer endpoints due to evidence suggesting that it may associate with cancer independent of obesity. In the current analyses, we examined the associations of lifetime recreational physical inactivity with renal and bladder cancer risk.
In this hospital-based case-control study, we identified N=160 renal cancer patients, N=208 bladder cancer patients, and N=766 age frequency-matched controls without cancer. Participants self-reporting never participating in any regular/weekly recreational physical activity throughout their lifetime were classified as physically inactive. Utilizing unconditional multivariable logistic regression analyses, we estimated odds ratios and 95% confidence intervals to represent the associations between lifetime physical inactivity and renal and bladder cancer risk.
In multivariable logistic regression models, we observed significant positive associations between lifetime recreational physical inactivity and renal cancer and bladder cancer risk: odds ratio=1.77 (95% CI: 1.10-2.85) and odds ratio=1.73 (95% CI: 1.13-2.63), respectively. Similar associations also persisted among individuals who were not obese for both renal and bladder cancer: odds ratio=1.75 (95% CI: 1.03-2.98) and odds ratio=1.70 (95% CI: 1.08-2.69), respectively.
In this case-control study, we observed evidence of a positive association between renal and bladder cancer with lifetime recreational physical inactivity. These data add to the growing body of evidence suggesting that physical inactivity may be an important independent risk factor for cancer. However, additional studies using a larger sample and prospectively collected data are needed to substantiate the current findings.
由于有证据表明休闲性身体活动不足可能独立于肥胖与癌症相关，因此它作为一种与癌症终点相关的独立流行病学暴露因素，已越来越受到认可。在当前的分析中，我们研究了终生休闲性身体活动不足与肾癌和膀胱癌风险之间的关联。
在这项基于医院的病例对照研究中，我们确定了160例肾癌患者、208例膀胱癌患者以及766例年龄频率匹配的无癌对照。终生自我报告从未参加过任何定期/每周休闲性体育活动的参与者被归类为身体活动不足。利用无条件多变量逻辑回归分析，我们估计了优势比和95%置信区间，以表示终生身体活动不足与肾癌和膀胱癌风险之间的关联。
在多变量逻辑回归模型中，我们观察到终生休闲性身体活动不足与肾癌和膀胱癌风险之间存在显著的正相关：优势比分别为1.77（95%置信区间：1.10 - 2.85）和1.73（95%置信区间：1.13 - 2.63）。在非肥胖个体中，肾癌和膀胱癌也存在类似的关联：优势比分别为1.75（95%置信区间：1.03 - 2.98）和1.70（95%置信区间：1.08 - 2.69）。
在这项病例对照研究中，我们观察到肾癌和膀胱癌与终生休闲性身体活动不足之间存在正相关的证据。这些数据进一步证明了身体活动不足可能是癌症的一个重要独立危险因素。然而，需要更多使用更大样本和前瞻性收集数据的研究来证实当前的发现。
