解析非编码RNA在肿瘤微环境中的进展：癌症治疗的创新策略。
Unraveling the advances of non-coding RNAs on the tumor microenvironment: innovative strategies for cancer therapies.
作者信息
Mu Deyang, Han Bing, Huang Hao, Zheng Yuchen, Zhang Jungang, Shi Ying
机构信息
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, P.R. China.
Department of Pharmacology, School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, 311300, P.R. China.
出版信息
J Transl Med. 2025 Jun 2;23(1):614. doi: 10.1186/s12967-025-06629-6.
Non-coding RNAs (ncRNAs) are crucial molecules that do not encode proteins but play roles in regulating various biological processes. Recent research highlights that ncRNAs not only control gene expression within cells but also facilitate intercellular communication via exosomes and other carriers. This function is vital in the tumor microenvironment (TME). Our review covers the structure and functions of different ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). We examine how these ncRNAs influence tumor initiation and progression. Additionally, we explore their role in promoting tumor growth or immune evasion by modulating the TME. The potential of using these ncRNAs as therapeutic targets or biomarkers for clinical use is also discussed. As our understanding of ncRNAs grows, the development of new therapies based on ncRNAs is anticipated to offer improved treatment options for cancer patients.
非编码RNA（ncRNAs）是一类至关重要的分子，它们不编码蛋白质，但在调节各种生物学过程中发挥作用。最近的研究强调，ncRNAs不仅控制细胞内的基因表达，还通过外泌体和其他载体促进细胞间通讯。这一功能在肿瘤微环境（TME）中至关重要。我们的综述涵盖了不同ncRNAs的结构和功能，如微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）。我们研究了这些ncRNAs如何影响肿瘤的发生和发展。此外，我们探讨了它们通过调节TME在促进肿瘤生长或免疫逃逸中的作用。还讨论了将这些ncRNAs用作临床治疗靶点或生物标志物的潜力。随着我们对ncRNAs的了解不断深入，预计基于ncRNAs的新疗法的开发将为癌症患者提供更好的治疗选择。
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