Eytan Danielle F, Yin Linda X, Maleki Zahra, Koch Wayne M, Tufano Ralph P, Eisele David W, Boahene Kofi D O, Fakhry Carole, Bishop Justin A, Westra William H, Gourin Christine G
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, U.S.A.
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, U.S.A.
Laryngoscope. 2018 Feb;128(2):398-402. doi: 10.1002/lary.26776. Epub 2017 Aug 7.
Preoperative fine needle aspiration (FNA) of parotid lesions often is used in the initial evaluation of parotid masses, but its role in guiding surgical decision making remains unclear, in part due to varying diagnostic accuracy reported. We sought to evaluate the role of preoperative FNA in detection of malignancy and impact on surgical management.
Retrospective study.
The medical records of patients who underwent parotidectomy at a single tertiary medical center were reviewed from 2000 to 2015. Patients who had a preoperative FNA comprised the study cohort.
A total of 1,074 consecutive patients underwent parotidectomy during the study period; of those, 477 had a preoperative FNA. FNA was nondiagnostic in 26 cases. There were 29 false positives (6.4%), 26 false negatives (5.8%), 122 true positives (27.1%), and 274 true negatives (60.8%). The sensitivity and specificity of FNA were 82.4% and 90.4%, respectively, with a positive predictive value of 80.8% and a negative predictive value of 91.3%. The overall accuracy of preoperative FNA was 87.8%. The preoperative FNA resulted in a change in the surgical plan in 85 (18.9%) cases. In 66 of these cases (78%), surgery was extended to include neck dissection at time of resection. In 10 cases, FNA led to surgical management over surveillance. In 11 cases, FNA downgraded the extent of surgery planned to an excisional biopsy.
Preoperative FNA is a valuable adjunct in the surgical management of parotid lesions, with high specificity for the detection of malignant disease.
腮腺病变的术前细针穿刺抽吸术(FNA)常用于腮腺肿块的初步评估,但其在指导手术决策中的作用仍不明确,部分原因是报道的诊断准确性存在差异。我们旨在评估术前FNA在恶性肿瘤检测中的作用及其对手术管理的影响。
回顾性研究。
回顾了2000年至2015年在一家三级医疗中心接受腮腺切除术患者的病历。术前进行FNA的患者构成研究队列。
在研究期间,共有1074例连续患者接受了腮腺切除术;其中,477例患者进行了术前FNA。26例FNA结果无法诊断。有29例假阳性(6.4%),26例假阴性(5.8%),122例真阳性(27.1%),274例真阴性(60.8%)。FNA的敏感性和特异性分别为82.4%和90.4%,阳性预测值为80.8%,阴性预测值为91.3%。术前FNA的总体准确率为87.8%。术前FNA导致85例(18.9%)患者的手术计划发生改变。在其中66例(78%)患者中,手术扩大至切除时包括颈部清扫术。在10例患者中,FNA导致选择手术治疗而非观察。在11例患者中,FNA将计划的手术范围降级为切除活检。
术前FNA是腮腺病变手术管理中有价值的辅助手段,对恶性疾病的检测具有高特异性。
4。《喉镜》,2018年,第128卷,第398 - 402页。