Cook D G, Shaper A G, Pocock S J, Kussick S J
Lancet. 1986 Dec 13;2(8520):1376-80. doi: 10.1016/s0140-6736(86)92017-9.
In a prospective study of 7735 middle-aged men, both current and ex-cigarette-smokers had a risk of a major IHD event, within an average 6.2 years of screening, more than twice that in men who had never smoked cigarettes; men who had given up smoking more than 20 years ago still had an increased risk. This excess risk among ex-smokers is only to a small extent explained by their higher blood pressure, serum total cholesterol, and body-mass index. An increased prevalence of IHD in men who had recently given up smoking also made a small contribution to excess risk. In both current and former cigarette smokers, the number of years a man had smoked cigarettes ("smoking-years") was the clearest indicator of IHD risk due to cigarettes. The major benefit of giving up smoking may lie in halting the accumulation of smoking years.
在一项针对7735名中年男性的前瞻性研究中，当前吸烟者和既往吸烟者在平均6.2年的筛查期内发生主要缺血性心脏病（IHD）事件的风险，是从不吸烟男性的两倍多；那些在20多年前就戒烟的男性仍然有较高的风险。既往吸烟者中这种额外的风险，仅有一小部分可归因于他们较高的血压、血清总胆固醇和体重指数。近期戒烟男性中IHD患病率的增加，也对额外风险有少量影响。在当前和既往吸烟者中，男性吸烟的年数（“吸烟年数”）是吸烟导致IHD风险最明显的指标。戒烟的主要益处可能在于停止吸烟年数的累积。
