Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650204, China.
Org Lett. 2017 Aug 18;19(16):4399-4402. doi: 10.1021/acs.orglett.7b02146. Epub 2017 Aug 7.
Aspergilasines A-D (1-4), four merocytochalasans with new skeletons, were isolated from the liquid culture broth of Aspergillus flavipes QCS12. Aspergilasine A (1) possesses a uniquely caged pentacyclo[7.2.0.1.0.0]dodecane skeleton with an unexpected cyclobutane ring that formed by the fusion of two epicoccine moieties via two [3 + 2] cycloadditions. Aspergilasines B-D (2-4) are key biosynthetic intermediates of epicochalasine B that fit well with our previous biosynthetic proposal.
黄曲霉毒素 A-D（1-4），四种具有新骨架的单环倍半萜生物碱，从黄曲霉 QCS12 的液体培养物中分离得到。黄曲霉毒素 A（1）具有独特的笼状五环[7.2.0.1.0.0]十二烷骨架，其中一个意想不到的环丁烷环是通过两个 epicoccine 部分通过两个 [3 + 2] 环加成融合形成的。黄曲霉毒素 B-D（2-4）是 epicochalasine B 的关键生物合成中间体，与我们之前的生物合成假设相符。
