千里光裂碱和聚合草碱对大鼠肝脏肿瘤的诱导作用。

Induction of hepatic tumors in rats by senkirkine and symphytine.

作者信息

Hirono I, Haga M, Fujii M, Matsuura S, Matsubara N, Nakayama M, Furuya T, Hikichi M, Takanashi H, Uchida E, Hosaka S, Ueno I

出版信息

J Natl Cancer Inst. 1979 Aug;63(2):469-72.

PMID:287835

Abstract

The carcinogenicity of the pyrrolizidine alkaloids senkirkine and symphytine was studied in male inbred ACI rats. Animals were divided into 3 groups: Group I received ip injections of freshly prepared senkirkine at a dose of 10% of the median lethal dose (LD50) twice weekly for 4 weeks and then once a week for 52 weeks. Group II received ip injections of symphytine at a dose of 10% of the LD50 by the same injection schedule as in group I. The control group was given ip injections of a 0.9% NaCl solution following the same injection schedule as in experimental groups. All group I rats survived for more than 290 days after the start of injections, and 9 of 20 rats developed liver cell adenoma. All group II animals survived for more than 330 days after the start of injections. Of 20 rats, 4 had liver tumors, 3 had hemangioendothelial sarcomas, and 1 had liver cell adenoma. The hemangioendothelial sarcomas showed metastasis in the lungs of 2 rats. The control group had no liver tumors.

摘要

在雄性近交系ACI大鼠中研究了吡咯里西啶生物碱千里光碱和聚合草碱的致癌性。动物被分为3组：第I组大鼠每周两次腹腔注射新鲜配制的千里光碱，剂量为半数致死量（LD50）的10%，持续4周，然后每周一次，持续52周。第II组大鼠按照与第I组相同的注射方案腹腔注射聚合草碱，剂量为LD50的10%。对照组按照与实验组相同的注射方案腹腔注射0.9%的氯化钠溶液。所有第I组大鼠在注射开始后存活超过290天，20只大鼠中有9只发生了肝细胞腺瘤。所有第II组动物在注射开始后存活超过330天。20只大鼠中，4只患有肝肿瘤，3只患有血管内皮肉瘤，1只患有肝细胞腺瘤。2只大鼠的血管内皮肉瘤出现了肺转移。对照组未出现肝肿瘤。