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分枝杆菌内酯对雪旺细胞的细胞毒性可解释布氏杆菌病中的神经损伤。

Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.

作者信息

En Junichiro, Kitamoto Sho, Kawashima Akira, Yonezawa Suguru, Kishi Yoshito, Ishii Norihisa, Goto Masamichi

机构信息

Department of Pathology, Kagoshima University, Kagoshima, Japan.

National Sanatorium Hoshizuka-Keiaien, Kanoya, Kagoshima, Japan.

出版信息

PLoS Negl Trop Dis. 2017 Aug 4;11(8):e0005834. doi: 10.1371/journal.pntd.0005834. eCollection 2017 Aug.

DOI:10.1371/journal.pntd.0005834
PMID:28783752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5559071/
Abstract

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer.

摘要

布氏杆菌溃疡是一种由溃疡分枝杆菌引起的慢性无痛性皮肤病。在布氏杆菌溃疡小鼠模型中，溃疡分枝杆菌入侵引起的局部神经损伤类似于注射毒素诱导的神经损伤。为了阐明这种神经损伤的机制，我们测试并比较了合成毒素A/B对培养的雪旺细胞、成纤维细胞和巨噬细胞的细胞毒性作用。毒素诱导雪旺细胞系SW10的细胞死亡和凋亡远高于成纤维细胞系L929。这些结果表明，毒素是布氏杆菌溃疡神经损伤产生的关键物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/72468b727aaf/pntd.0005834.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/64591088a7d1/pntd.0005834.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/dbafb95000c5/pntd.0005834.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/27f9d534af4a/pntd.0005834.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/f7d331a66b96/pntd.0005834.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/4658b606f883/pntd.0005834.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/72468b727aaf/pntd.0005834.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/64591088a7d1/pntd.0005834.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/dbafb95000c5/pntd.0005834.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/27f9d534af4a/pntd.0005834.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/f7d331a66b96/pntd.0005834.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/4658b606f883/pntd.0005834.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0d2/5559071/72468b727aaf/pntd.0005834.g006.jpg

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PLoS Negl Trop Dis. 2017 Feb 28;11(2):e0005331. doi: 10.1371/journal.pntd.0005331. eCollection 2017 Feb.
2
Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone.关于分枝杆菌内酯对Sec61依赖性共翻译和翻译后易位的抑制作用的机制性见解。
J Cell Sci. 2016 Apr 1;129(7):1404-15. doi: 10.1242/jcs.182352. Epub 2016 Feb 11.
3
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.
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Expert Rev Clin Pharmacol. 2020 Apr;13(4):391-401. doi: 10.1080/17512433.2020.1752663. Epub 2020 Apr 20.
4
Mycobacterium ulcerans mycolactones-fungi crosstalking.溃疡分枝杆菌(mycobacterium ulcerans) (mycolactones)-真菌串扰。
Sci Rep. 2019 Feb 28;9(1):3028. doi: 10.1038/s41598-019-39927-3.
5
Buruli Ulcer: a Review of the Current Knowledge.布鲁里溃疡：当前知识综述
Curr Trop Med Rep. 2018;5(4):247-256. doi: 10.1007/s40475-018-0166-2. Epub 2018 Sep 28.
6
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PLoS Negl Trop Dis. 2017 Nov 17;11(11):e0006058. doi: 10.1371/journal.pntd.0006058. eCollection 2017 Nov.
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PLoS Pathog. 2015 Jul 16;11(7):e1005011. doi: 10.1371/journal.ppat.1005011. eCollection 2015 Jul.
4
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5
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6
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9
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