Xin H N, Li H J, Li Z, Li X W, Li M F, Zhang H R, Feng B X, Lun W H, Yan H W, Long J, Gao L
Institute of Pathogen Biology, and Center for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China.
Chaoyang Center for Disease Control and Prevention,Beijing 100021,China.
Epidemiol Infect. 2017 Oct;145(13):2838-2847. doi: 10.1017/S0950268817001698. Epub 2017 Aug 8.
Human papillomavirus (HPV) has been identified as etiologic agent of various cancers for both men and women. However, HPV vaccine has not been recommended for men in China by far. To provide more evidences to promote HPV vaccination among males at high-risk of infection, this study investigated genital HPV genotypes among male attendees of sexually transmitted disease (STD) clinic. Male attendees (⩾18 years old) were recruited from STD clinic of Beijing Ditan Hospital. Data on sociodemographic characteristics and self-reported sexual behaviors were collected based on questionnaire. Genital swab specimens were collected for HPV genotypes. Finally, a total of 198 eligible participants were included in the study. Nearly half of them were infected with at least one type of HPV. The prevalence of genital infection among participants with only heterosexual behaviors (50·91%, 56/110) was significantly higher than those with only homosexual behaviors (36·36%, 32/88) (P < 0·001). However, the distribution pattern of the most frequently observed HPV subtypes were found to be similar between these two subgroups. HPV31, HPV18, HPV16 and HPV58 were the most frequently identified high-risk types and HPV11, HPV6, HPV81 and HPV61 were the most frequently observed low-risk types. Our results, although need further verification by larger sample size, suggested that currently available HPV vaccines covered most prevalent HPV types observed in Chinese men. As HPV vaccine has been approved for application in females in China, molecular epidemiological studies and intervention studies among high-risk males should be promoted as well.
人乳头瘤病毒（HPV）已被确认为导致男性和女性多种癌症的病原体。然而，到目前为止，中国尚未建议男性接种HPV疫苗。为了提供更多证据以促进高危感染男性接种HPV疫苗，本研究调查了性病门诊男性就诊者的生殖器HPV基因型。从北京地坛医院性病门诊招募了年龄在18岁及以上的男性就诊者。基于问卷收集社会人口学特征和自我报告的性行为数据。收集生殖器拭子标本进行HPV基因型检测。最终，共有198名符合条件的参与者纳入研究。其中近一半感染了至少一种HPV类型。仅具有异性性行为的参与者的生殖器感染率（50.91%，56/110）显著高于仅具有同性性行为的参与者（36.36%，32/88）（P<0.001）。然而，发现这两个亚组中最常见的HPV亚型的分布模式相似。HPV31、HPV18、HPV16和HPV58是最常鉴定出的高危型别，HPV11、HPV6、HPV81和HPV61是最常观察到的低危型别。我们的结果虽然需要更大样本量进一步验证，但表明目前可用的HPV疫苗涵盖了中国男性中观察到的大多数流行HPV类型。由于HPV疫苗在中国已获批用于女性，也应推动高危男性中的分子流行病学研究和干预研究。
