Chandra R, Singh I P, Garg S K, Varshney K C
Acta Virol. 1986 Sep;30(5):390-6.
Buffalo pox virus produced typical pock lesions on the skin of rabbits at the site of primary inoculation following an incubation period of 48-72 hr. Gross lesions in internal organs, characterized by focal or diffuse necrotic areas on lung, liver and spleen were seen from day 5 post-inoculation (p. i.). Isolated lesions of approximately 2 mm diameter appeared in skin, stomach, intestine and uterus from day 7 p. i. Histopathological changes, i. e. intra-alveolar and intra-bronchial haemorrhages were seen in lungs and severe fatty changes were found in the liver. Multinuclear cells were detected in liver during recovery. Virus particles were demonstrated by electron microscopy in skin, lung, liver and spleen lesions.
水牛痘病毒在接种48 - 72小时的潜伏期后，在兔子皮肤的初次接种部位产生典型的痘疱病变。接种后第5天（p.i.）可见内脏器官的大体病变，其特征为肺、肝和脾出现局灶性或弥漫性坏死区域。接种后第7天起，皮肤、胃、肠和子宫出现直径约2毫米的孤立病变。组织病理学变化方面，肺内可见肺泡内和支气管内出血，肝脏发现严重的脂肪变性。恢复期间在肝脏中检测到多核细胞。通过电子显微镜在皮肤、肺、肝和脾病变中证实了病毒颗粒的存在。
