细小病毒B19感染致急性肝衰竭死亡病例

Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure.

作者信息

Leon Luciane Almeida Amado, Alves Arthur Daniel Rocha, Garcia Rita de Cássia Nasser Cubel, Melgaço Juliana Gil, de Paula Vanessa Salete, Pinto Marcelo Alves

机构信息

From the *Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; and †Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, Brasil.

出版信息

Pediatr Infect Dis J. 2017 Dec;36(12):e355-e358. doi: 10.1097/INF.0000000000001731.

DOI:10.1097/INF.0000000000001731

PMID:28787384

Abstract

B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined with the detection of anti-B19 Immunoglobulin G (IgG), B19 DNA and B19 mRNA in liver indicate a persistent infection and suggest a diagnosis of parvovirus B19-associated acute liver failure.

摘要

B19病毒已被提出作为肝炎的病原体，主要发生在儿童中，但这是一种罕见的临床情况。在本文中，我们报告了一例免疫功能正常的儿童感染B19后发生非甲-戊型急性肝衰竭的病例。严重贫血和全血细胞减少的临床症状，结合在肝脏中检测到抗B19免疫球蛋白G（IgG）、B19 DNA和B19 mRNA，表明存在持续性感染，并提示诊断为细小病毒B19相关急性肝衰竭。