Matsuo Koji, Wong Kwong-Kwok, Fotopoulou Christina, Blake Erin A, Robertson Sharon E, Pejovic Tanja, Frimer Marina, Pardeshi Vishakha, Hu Wei, Choi Jong-Sun, Sun Charlotte C, Richmond Abby M, Marcus Jenna Z, Hilliard Maren A M, Mostofizadeh Sayedamin, Mhawech-Fauceglia Paulette, Abdulfatah Eman, Post Miriam D, Saglam Ozlen, Shahzad Mian M K, Karabakhtsian Rouzan G, Ali-Fehmi Rouba, Gabra Hani, Roman Lynda D, Sood Anil K, Gershenson David M
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California.
Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J Surg Oncol. 2018 Feb;117(2):236-244. doi: 10.1002/jso.24801. Epub 2017 Aug 8.
To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI.
This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome.
LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047).
LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.
研究淋巴管间隙浸润（LVSI）与临床病理因素的相关性，并评估存在LVSI区域的低级别浆液性卵巢癌女性患者的生存率。
这是一项多中心回顾性研究，纳入了连续接受手术治疗的Ⅰ-Ⅳ期低级别浆液性卵巢癌患者（n = 178例）。对存档的卵巢肿瘤组织病理学切片进行复查，LVSI分为存在或不存在。将LVSI状态与临床病理结果及生存结局进行关联分析。
79例（44.4%，95%置信区间[CI] 37.1-51.7）存在LVSI。LVSI与网膜转移风险增加相关（87.0%对64.9%，比值比[OR] 3.62，P = 0.001）、高盆腔淋巴结比例（中位数12.9%对0%，P = 0.012）以及恶性腹水（49.3%对32.6%，OR 2.01，P = 0.035）。多变量分析中，在控制年龄、分期和肿瘤细胞减灭状态后，卵巢肿瘤中存在LVSI仍然是无进展生存期降低的独立预测因素（5年率21.0%对35.7%，校正风险比1.57，95%CI 1.06-2.34，P = 0.026）。LVSI与淋巴结复发风险增加显著相关（OR 2.62，95%CI 1.08-6.35，P = 0.047）。
卵巢肿瘤中的LVSI与不良临床病理特征相关，并降低低级别浆液性卵巢癌女性患者的无进展生存期。
