Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Parkland Drive, Southport, Queensland, 4222, Australia; National Centre of Hematology, Almustansiriah University, Alyarmook, Baghdad, Iraq.
Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Parkland Drive, Southport, Queensland, 4222, Australia.
Biomed Pharmacother. 2017 Oct;94:679-686. doi: 10.1016/j.biopha.2017.07.121. Epub 2017 Aug 16.
One of the most commonly identified chronic illnesses in many countries is type 2 diabetes mellitus (T2DM). T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complications. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Besides hyperglycemia, oxidative stress plays a significant role in the pathogenesis of diabetes and its associated risk of CVD. There are many other factors including molecular, metabolic, lipid, fibrinolytic, and platelet function disorders precipitate to thrombotic and CVD risks in T2DM. Also, Platelets have an increased response to procoagulants in patients with diabetes. Platelet hyperactivity, in the presence of oxidative stress, has a major effect on the progression of thrombotic and CVD events. This review will discuss the impact of the above factors and the potential effects of platelet hyperactivity on thrombotic and cardiovascular risks.
在许多国家，最常见的慢性疾病之一是 2 型糖尿病（T2DM）。T2DM 是心血管疾病（CVD）的独立危险因素。心脏病是糖尿病患者死亡的原因之一，主要是由于大血管并发症。糖尿病的大血管并发症之一是动脉粥样硬化，它涉及一个复杂的病理生理过程。除了高血糖，氧化应激在糖尿病的发病机制及其相关的 CVD 风险中起着重要作用。还有许多其他因素，包括分子、代谢、脂质、纤溶和血小板功能障碍，导致 T2DM 中的血栓形成和 CVD 风险增加。此外，糖尿病患者的血小板对促凝剂的反应增加。在氧化应激的情况下，血小板的高活性对血栓形成和 CVD 事件的进展有重大影响。这篇综述将讨论上述因素的影响以及血小板高活性对血栓形成和心血管风险的潜在影响。
