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磺胺嘧啶-壳聚糖共轭物及其与透明质酸盐形成的聚电解质复合物用于烧伤创面处理

Sulfadiazine-Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds.

作者信息

Dumitriu Raluca Petronela, Profire Lenuta, Nita Loredana Elena, Dragostin Oana Maria, Ghetu Nicolae, Pieptu Dragoș, Vasile Cornelia

机构信息

Petru Poni" Institute of Macromolecular Chemistry, Department of Physical Chemistry of Polymers, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

Grigore T. Popa" University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 16 University Street, 700115 Iasi, Romania.

出版信息

Materials (Basel). 2015 Jan 16;8(1):317-338. doi: 10.3390/ma8010317.

DOI:10.3390/ma8010317
PMID:28787940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5455235/
Abstract

In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: , and . The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan.

摘要

在本研究中，基于新型磺胺嘧啶-壳聚糖共轭物与透明质酸钠的聚电解质复合物（PEC）已被开发出来，具有用于治疗烧伤创面的潜在用途。使用傅里叶变换红外光谱、扫描电子显微镜和近红外化学成像技术对PEC进行了化学表征。还研究了其溶胀行为和磺胺嘧啶释放情况。对三种细菌菌株： 、 和 评估了抗菌活性。所开发的PEC对测试的细菌菌株显示出抗菌效率，含有磺胺嘧啶修饰壳聚糖的PEC比含有未修饰壳聚糖的PEC更具活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e6a/5455235/d8ee227f703c/materials-08-00317-g001.jpg

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