骨形态发生蛋白：适应症与用途。

Bone morphogenetic proteins: indications and uses.

作者信息

Bibbo Christopher, Nelson Jonas, Ehrlich David, Rougeux Brian

机构信息

Department of Orthopaedics, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI, USA; Division of Plastic & Reconstructive Surgery, Department of Surgery, Hospital of the University of Pennsylvania, 10 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Division of Plastic & Reconstructive Surgery, Department of Surgery, Hospital of the University of Pennsylvania, 10 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, USA.

出版信息

Clin Podiatr Med Surg. 2015 Jan;32(1):35-43. doi: 10.1016/j.cpm.2014.09.005. Epub 2014 Oct 18.

DOI:10.1016/j.cpm.2014.09.005

PMID:25440416

Abstract

The BMPs are a group of growth factors that have varied roles in the development and maintenance of many organ systems. Several of the BMPs have osteogenic potential, and exert their effects via complex and highly regulated pathways. At present, only rhBMP-2 and rhBMP-7 are available for clinical use, but only rhBMP-2 is readily available, and from a practical standpoint is considered the only commercially available BMP. Only a few studies exist on BMP use in foot and ankle surgery, but these have shown promising results with low complication rates. BMP is an adjuvant to bone healing,and does not substitute for structural bone needs. In addition, rhBMP-2 outside spinal fusions is considered to be US Food and Drug Administration off-label, and should be used only in patients who are at high risk for bone healing problems.

摘要

骨形态发生蛋白（BMPs）是一组生长因子，在许多器官系统的发育和维持中具有多种作用。几种BMPs具有成骨潜力，并通过复杂且高度调控的途径发挥作用。目前，仅有重组人骨形态发生蛋白-2（rhBMP-2）和重组人骨形态发生蛋白-7（rhBMP-7）可用于临床，但只有rhBMP-2容易获得，从实际角度来看，它被认为是唯一可商购的BMP。关于BMP在足踝外科手术中的应用仅有少数研究，但这些研究显示出了令人鼓舞的结果，并发症发生率较低。BMP是骨愈合的辅助剂，不能替代结构性骨需求。此外，脊柱融合术以外使用rhBMP-2被美国食品药品监督管理局视为超说明书用药，仅应在骨愈合问题高风险患者中使用。