Abdulghafor Mohammed Aso, Mahmood Mohammed Khalid, Tassery Herve, Tardivo Delphine, Falguiere Arthur, Lan Romain
College of Dentistry, University of Sulaimani, Sulaimani 46001, Kurdistan, Iraq.
Faculty of Dentistry, Aix-Marseille University, CNRS, EFS, ADES, 13284 Marseille, France.
J Funct Biomater. 2023 Dec 30;15(1):15. doi: 10.3390/jfb15010015.
Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface's chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied to improve osseointegration and decrease peri-implantitis. The surface medication increases surface energy, leading to enhanced cell proliferation and growth factors, and, consequently, to a rise in the osseointegration process. This review provides a comprehensive update on the numerous biomimetic coatings used to improve the surface characteristics of dental implants and their applications in two main categories: coating to improve osseointegration, including the hydroxyapatite layer and nanocomposites, growth factors (BMPs, PDGF, FGF), and extracellular matrix (collagen, elastin, fibronectin, chondroitin sulfate, hyaluronan, and other proteoglycans), and coatings for anti-bacterial performance, covering drug-coated dental implants (antibiotic, statin, and bisphosphonate), antimicrobial peptide coating (GL13K and human beta defensins), polysaccharide antibacterial coatings (natural chitosan and its coupling agents) and metal elements (silver, zinc, and copper).
仿生牙种植体被视为种植体表面改性领域近年来的临床进展之一。不同厚度和粗糙度的涂层可能会影响牙种植体表面的化学惰性、细胞粘附和抗菌特性。人们研究了不同的表面涂层和机械表面变化，以改善骨整合并减少种植体周围炎。表面处理增加了表面能，导致细胞增殖和生长因子增强，从而使骨整合过程加快。本综述全面更新了用于改善牙种植体表面特性的多种仿生涂层及其在两大类中的应用：用于改善骨整合的涂层，包括羟基磷灰石层和纳米复合材料、生长因子（骨形态发生蛋白、血小板衍生生长因子、成纤维细胞生长因子）以及细胞外基质（胶原蛋白、弹性蛋白、纤连蛋白、硫酸软骨素、透明质酸和其他蛋白聚糖）；用于抗菌性能的涂层，涵盖药物涂层牙种植体（抗生素、他汀类药物和双膦酸盐）、抗菌肽涂层（GL13K和人β防御素）、多糖抗菌涂层（天然壳聚糖及其偶联剂）和金属元素（银、锌和铜）。
