Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia.
Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia; School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia.
Semin Cell Dev Biol. 2018 Mar;75:50-60. doi: 10.1016/j.semcdb.2017.08.008. Epub 2017 Aug 5.
Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes.
上皮细胞和间充质状态之间的相互转换，通常被称为上皮间质转化（EMT）及其逆转 MET，在胚胎发育中发挥重要作用，并在包括癌症进展在内的各种成人病理中再现。这些转换受复杂的转录和转录后机制调节，包括由特定剪接因子协调的选择性剪接程序。本综述将重点介绍我们对调节与癌症进展和多能性诱导相关的上皮间质可塑性的剪接因子的最新理解，包括最近在这些过程中涉及的环状 RNA（circRNA）的潜在作用。
