Freemark M, Stoff D M, Moja E A, Gillin J C, Wyatt R J
Biol Psychiatry. 1978 Aug;13(4):455-63.
Testosterone pretreatment (1.0-4.0 mg/kg) attenuated, in a dose-response fashion, the induction of stereotyped behavior and hyperactivity by pargyline (0.25, 4.0 mg/kg) and beta-phenylethylamine (8.0, 16.0 mg/kg) in preubertal, male rats. The dyskinetic movements induced by pargyline and beta-phenylethylamine were proposed as a possible animal model for tardive dyskinesias. Attenuation by testosterone of these effects suggested an hormonal involvement consistent with the reported predominant occurrence of tardive dyskinesias in women and in the elderly.
睾酮预处理（1.0 - 4.0毫克/千克）以剂量反应方式减弱了在青春期前雄性大鼠中，优降宁（0.25、4.0毫克/千克）和β-苯乙胺（8.0、16.0毫克/千克）诱导的刻板行为和多动。优降宁和β-苯乙胺诱导的运动障碍被提议作为迟发性运动障碍的一种可能的动物模型。睾酮对这些作用的减弱表明激素参与其中，这与报道的迟发性运动障碍在女性和老年人中主要发生的情况一致。
