Naik S R, Kelkar M R, Sheth U K
Psychopharmacology (Berl). 1978 Apr 28;57(2):211-4. doi: 10.1007/BF00426890.
Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced sterotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sec steroids on SB through changes in central neurotransmitters are discussed.
已在正常、去势和卵巢切除的小鼠中研究了性类固醇、睾酮、孕酮和雌二醇对苯乙胺（PEA）诱导的刻板行为（SB）的影响。还描述了性类固醇对苯丙胺诱导的刻板行为和多动的影响。在去势和卵巢切除的小鼠中，β-苯乙胺（PEA）增加了刻板行为。用性类固醇预处理可减轻正常、去势和卵巢切除小鼠中PEA诱导的刻板行为。性类固醇预处理显著抑制了PEA和苯丙胺诱导的刻板行为，但未能改变苯丙胺或PEA引起的运动活动增加。讨论了性类固醇通过中枢神经递质变化对刻板行为的可能影响。
