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反对血管活性肠肽参与小鼠肛门尾骨肌神经源性舒张的证据。

Evidence against VIP-involvement in neurogenic relaxations of the mouse anococcygeus muscle.

作者信息

Carvajal A, Gibson A, Yu O

出版信息

J Pharm Pharmacol. 1986 Oct;38(10):767-9. doi: 10.1111/j.2042-7158.1986.tb04488.x.

DOI:10.1111/j.2042-7158.1986.tb04488.x
PMID:2879000
Abstract

Vasoactive intestinal polypeptide (VIP) antiserum, alpha-chymotrypsin, and repeated exposure to VIP markedly reduced relaxations of the mouse anococcygeus muscle to VIP but not to field stimulation. This evidence suggests that VIP does not mediate non-adrenergic, non-cholinergic relaxations in the mouse anococcygeus.

摘要

血管活性肠肽（VIP）抗血清、α-糜蛋白酶以及反复接触VIP均可显著降低小鼠肛门尾骨肌对VIP的舒张反应，但对场刺激引起的舒张反应无影响。这一证据表明，VIP并不介导小鼠肛门尾骨肌的非肾上腺素能、非胆碱能舒张反应。

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Evidence against VIP-involvement in neurogenic relaxations of the mouse anococcygeus muscle.反对血管活性肠肽参与小鼠肛门尾骨肌神经源性舒张的证据。
J Pharm Pharmacol. 1986 Oct;38(10):767-9. doi: 10.1111/j.2042-7158.1986.tb04488.x.
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Similarities between the relaxations induced by vasoactive intestinal peptide and by stimulation of the non-adrenergic non-cholinergic neurons in the rat stomach.血管活性肠肽诱导的舒张与大鼠胃中非肾上腺素能非胆碱能神经元刺激所诱导的舒张之间的相似性。
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Influence of alpha-chymotrypsin and trypsin on the non-adrenergic non-cholinergic relaxation in the rat gastric fundus.α-糜蛋白酶和胰蛋白酶对大鼠胃底非肾上腺素能非胆碱能舒张的影响。
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Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli.关于血管活性肠肽并非从豚鼠结肠带平滑肌神经释放的非肾上腺素能、非胆碱能抑制性递质的证据。
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Vasoactive intestinal polypeptide. A neurotransmitter for lower esophageal sphincter relaxation.血管活性肠肽。一种用于下食管括约肌松弛的神经递质。
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引用本文的文献

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N-methylhydroxylamine inhibits and M&B 22948 potentiates relaxations of the mouse anococcygeus to non-adrenergic, non-cholinergic field stimulation and to nitrovasodilator drugs.N-甲基羟胺抑制而M&B 22948增强小鼠肛门尾骨肌对非肾上腺素能、非胆碱能场刺激以及对硝基血管扩张剂药物的舒张反应。
Br J Pharmacol. 1989 Mar;96(3):637-44. doi: 10.1111/j.1476-5381.1989.tb11863.x.
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Innervation of the anococcygeus muscle of the rat.大鼠肛门尾骨肌的神经支配。
Cell Tissue Res. 1990 Jan;259(1):139-46. doi: 10.1007/BF00571438.