反对血管活性肠肽参与小鼠肛门尾骨肌神经源性舒张的证据。
Evidence against VIP-involvement in neurogenic relaxations of the mouse anococcygeus muscle.
作者信息
Carvajal A, Gibson A, Yu O
出版信息
J Pharm Pharmacol. 1986 Oct;38(10):767-9. doi: 10.1111/j.2042-7158.1986.tb04488.x.
Abstract
Vasoactive intestinal polypeptide (VIP) antiserum, alpha-chymotrypsin, and repeated exposure to VIP markedly reduced relaxations of the mouse anococcygeus muscle to VIP but not to field stimulation. This evidence suggests that VIP does not mediate non-adrenergic, non-cholinergic relaxations in the mouse anococcygeus.
摘要
血管活性肠肽（VIP）抗血清、α-糜蛋白酶以及反复接触VIP均可显著降低小鼠肛门尾骨肌对VIP的舒张反应，但对场刺激引起的舒张反应无影响。这一证据表明，VIP并不介导小鼠肛门尾骨肌的非肾上腺素能、非胆碱能舒张反应。
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