Misra R N, Praharaj A K, Chander Yogesh
Classified Specialist (Pathology), INHS Asvini, Colaba, Mumbai.
Reader, Department of Microbiology, Armed Forces Medical College, Pune 411 040.
Med J Armed Forces India. 2000 Jan;56(1):50-52. doi: 10.1016/S0377-1237(17)30092-8. Epub 2017 Jun 8.
CD4 receptor molecules on 'T' lymphocytes and macrophages have already been identified as the route of entry for HIV. However CCR5 and CXCR4 are identified only recently as the second receptors for HIV on macrophages and 'T' lymphocytes respectively. Presence of homozygous CCR5 Δ 32, a defective CCR5 gene leads to resistance to HIV infection in the risk groups. While heterozygous CCRS Δ 32 leads to delay in the progress of HIV infection to AIDS.
“T”淋巴细胞和巨噬细胞上的CD4受体分子已被确定为HIV的进入途径。然而，CCR5和CXCR4直到最近才分别被确定为HIV在巨噬细胞和“T”淋巴细胞上的第二种受体。纯合子CCR5 Δ 32（一种有缺陷的CCR5基因）的存在会使高危人群对HIV感染产生抗性。而杂合子CCR5 Δ 32会导致HIV感染发展为艾滋病的进程延迟。
