HIV致病机制——新出现的概念
HIV PATHOGENESIS-EMERGING CONCEPTS.
作者信息
Misra R N, Praharaj A K, Chander Yogesh
机构信息
Classified Specialist (Pathology), INHS Asvini, Colaba, Mumbai.
Reader, Department of Microbiology, Armed Forces Medical College, Pune 411 040.
出版信息
Med J Armed Forces India. 2000 Jan;56(1):50-52. doi: 10.1016/S0377-1237(17)30092-8. Epub 2017 Jun 8.
Abstract
CD4 receptor molecules on 'T' lymphocytes and macrophages have already been identified as the route of entry for HIV. However CCR5 and CXCR4 are identified only recently as the second receptors for HIV on macrophages and 'T' lymphocytes respectively. Presence of homozygous CCR5 Δ 32, a defective CCR5 gene leads to resistance to HIV infection in the risk groups. While heterozygous CCRS Δ 32 leads to delay in the progress of HIV infection to AIDS.
摘要
“T”淋巴细胞和巨噬细胞上的CD4受体分子已被确定为HIV的进入途径。然而，CCR5和CXCR4直到最近才分别被确定为HIV在巨噬细胞和“T”淋巴细胞上的第二种受体。纯合子CCR5 Δ 32（一种有缺陷的CCR5基因）的存在会使高危人群对HIV感染产生抗性。而杂合子CCR5 Δ 32会导致HIV感染发展为艾滋病的进程延迟。
相似文献
1
HIV PATHOGENESIS-EMERGING CONCEPTS.HIV致病机制——新出现的概念
Med J Armed Forces India. 2000 Jan;56(1):50-52. doi: 10.1016/S0377-1237(17)30092-8. Epub 2017 Jun 8.
2
[Deep lung--cellular reaction to HIV].[深部肺脏——对HIV的细胞反应]
Rev Port Pneumol. 2007 Mar-Apr;13(2):175-212.
3
Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.CCR5在人免疫缺陷病毒巨噬细胞嗜性毒株感染原代巨噬细胞和淋巴细胞中的作用：因CCR5基因缺失突变导致对患者来源毒株和原型毒株的抗性
J Virol. 1997 Apr;71(4):3219-27. doi: 10.1128/JVI.71.4.3219-3227.1997.
4
CD4 receptor-dependent entry of human immunodeficiency virus type-1 env-pseudotypes into CCR5-, CCR3-, and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor.人类免疫缺陷病毒1型包膜假型通过CD4受体依赖方式进入表达CCR5、CCR3和CXCR4的人肺泡巨噬细胞，这一过程优先由CCR5共受体介导。
Am J Respir Cell Mol Biol. 1999 May;20(5):864-71. doi: 10.1165/ajrcmb.20.5.3547.
5
Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains.Tat蛋白可诱导1型人类免疫缺陷病毒（HIV-1）共受体，并促进巨噬细胞嗜性和T淋巴细胞嗜性HIV-1毒株的感染。
J Virol. 1998 Nov;72(11):8952-60. doi: 10.1128/JVI.72.11.8952-8960.1998.
6
The puzzling role of CXCR4 in human immunodeficiency virus infection.CXCR4 在人类免疫缺陷病毒感染中的令人费解的作用。
Theranostics. 2013;3(1):18-25. doi: 10.7150/thno.5392. Epub 2013 Jan 13.
7
8
Chemokines as natural HIV antagonists.趋化因子作为天然的HIV拮抗剂。
Curr Mol Med. 2002 Dec;2(8):691-702. doi: 10.2174/1566524023361862.
9
10
Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1.1型人类免疫缺陷病毒不同原始分离株对趋化因子共受体的利用情况
J Virol. 1998 Nov;72(11):9307-12. doi: 10.1128/JVI.72.11.9307-9312.1998.
本文引用的文献
1
Acute human immunodeficiency virus type 1 infection.急性1型人类免疫缺陷病毒感染
N Engl J Med. 1998 Jul 2;339(1):33-9. doi: 10.1056/NEJM199807023390107.
2
Chemokines--chemotactic cytokines that mediate inflammation.趋化因子——介导炎症的趋化性细胞因子。
N Engl J Med. 1998 Feb 12;338(7):436-45. doi: 10.1056/NEJM199802123380706.
3
Chemokine receptors and genetic variability: another leap in HIV research.
JAMA. 1998 Jan 28;279(4):317-8. doi: 10.1001/jama.279.4.317.
4
CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group.CCR5趋化因子受体变异与HIV-1母婴传播及儿童疾病进展。法国儿科HIV感染研究小组。
JAMA. 1998 Jan 28;279(4):277-80. doi: 10.1001/jama.279.4.277.
5
Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC).一种SDF-1趋化因子基因变体对艾滋病发病机制的遗传限制。ALIVE研究、血友病生长与发育研究（HGDS）、多中心艾滋病队列研究（MACS）、多中心血友病队列研究（MHCS）、旧金山城市队列（SFCC）。
Science. 1998 Jan 16;279(5349):389-93. doi: 10.1126/science.279.5349.389.
6
In search of AIDS-resistance genes.
Sci Am. 1997 Sep;277(3):44-51. doi: 10.1038/scientificamerican0997-44.
7
8
HIV-1 infection in a man homozygous for CCR5 delta 32.一名CCR5基因delta 32纯合子男性感染了HIV-1。
Lancet. 1997 Apr 26;349(9060):1219. doi: 10.1016/s0140-6736(97)24017-1.
9
Chemokines: leucocyte recruitment and activation cytokines.趋化因子：白细胞募集与激活细胞因子。
Lancet. 1997 Feb 15;349(9050):490-5. doi: 10.1016/s0140-6736(96)07524-1.
10
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.HIV-1共受体的纯合缺陷导致一些多次暴露个体对HIV-1感染具有抗性。
Cell. 1996 Aug 9;86(3):367-77. doi: 10.1016/s0092-8674(00)80110-5.
Zotero 插件