Patin Emmanuel C, Orr Selinda Jane, Schaible Ulrich E
Priority Area Infections, Department Cellular Microbiology, Forschungszentrum Borstel, and German Center for Infection Research, TTU-TB, Borstel, Germany.
Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Front Immunol. 2017 Jul 25;8:861. doi: 10.3389/fimmu.2017.00861. eCollection 2017.
The macrophage-inducible C-type lectin (Mincle) is an innate immune receptor on myeloid cells sensing diverse entities including pathogens and damaged cells. Mincle was first described as a receptor for the mycobacterial cell wall glycolipid, trehalose-6,6'-dimycolate, or cord factor, and the mammalian necrotic cell-derived alarmin histone deacetylase complex unit Sin3-associated protein 130. Upon engagement by its ligands, Mincle induces secretion of innate cytokines and other immune mediators modulating inflammation and immunity. Since its discovery more than 25 years ago, the understanding of Mincle's immune function has made significant advances in recent years. In addition to mediating immune responses to infectious agents, Mincle has been linked to promote tumor progression, autoimmunity, and sterile inflammation; however, further studies are required to completely unravel the complex role of Mincle in these distinct host responses. In this review, we discuss recent findings on Mincle's biology with an emphasis on its diverse functions in immunity.
巨噬细胞诱导性C型凝集素（Mincle）是髓系细胞上的一种天然免疫受体，可感知包括病原体和受损细胞在内的多种物质。Mincle最初被描述为分枝杆菌细胞壁糖脂海藻糖-6,6'-二霉菌酸酯（即索状因子）以及哺乳动物坏死细胞衍生的警报素组蛋白脱乙酰酶复合体亚基Sin3相关蛋白130的受体。在与配体结合后，Mincle会诱导天然细胞因子和其他免疫介质的分泌，从而调节炎症和免疫。自25多年前被发现以来，近年来对Mincle免疫功能的认识取得了重大进展。除了介导对感染因子的免疫反应外，Mincle还与促进肿瘤进展、自身免疫和无菌性炎症有关；然而，需要进一步研究以完全阐明Mincle在这些不同宿主反应中的复杂作用。在这篇综述中，我们讨论了关于Mincle生物学的最新发现，重点是其在免疫中的多种功能。
