Granja Andreia, Frias Iúri, Neves Ana Rute, Pinheiro Marina, Reis Salette
UCIBIO, REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Biomed Res Int. 2017;2017:5813793. doi: 10.1155/2017/5813793. Epub 2017 Jul 16.
Nowadays, the society is facing a large health problem with the rising of new diseases, including cancer, heart diseases, diabetes, neurodegenerative diseases, and obesity. Thus, it is important to invest in substances that enhance the health of the population. In this context, epigallocatechin gallate (EGCG) is a flavonoid found in many plants, especially in tea. Several studies support the notion that EGCG has several benefits in fighting cancer, heart diseases, diabetes, and obesity, among others. Nevertheless, the poor intestinal absorbance and instability of EGCG constitute the main drawback to use this molecule in prevention and therapy. The encapsulation of EGCG in nanocarriers leads to its enhanced stability and higher therapeutic effects. A comprehensive review of studies currently available on the encapsulation of EGCG by means of nanocarriers will be addressed.
如今，随着新疾病的不断涌现，包括癌症、心脏病、糖尿病、神经退行性疾病和肥胖症等，社会正面临着一个重大的健康问题。因此，投资于能够增进民众健康的物质非常重要。在此背景下，表没食子儿茶素没食子酸酯（EGCG）是一种存在于许多植物中的类黄酮，尤其是茶叶中。多项研究支持了EGCG在对抗癌症、心脏病、糖尿病和肥胖症等方面具有多种益处的观点。然而，EGCG较差的肠道吸收率和不稳定性构成了在预防和治疗中使用该分子的主要障碍。将EGCG封装在纳米载体中可提高其稳定性并增强治疗效果。本文将对目前有关通过纳米载体封装EGCG的研究进行全面综述。
