Park Jae-Hyung, Bae Jae-Hoon, Im Sung-Soon, Song Dae-Kyu
Department of Physiology, Keimyung University School of Medicine, Daegu, Korea.
Integr Med Res. 2014 Mar;3(1):4-10. doi: 10.1016/j.imr.2013.12.002. Epub 2013 Dec 14.
Green tea and coffee consumption have been widely popular worldwide. These beverages contain caffeine to activate the central nervous system by adenosine receptor blockade, and due to the caffeine, addiction or tolerance may occur. In addition to this caffeine effect, green tea and coffee consumption have always been at the center of discussions about human health, disease, and longevity. In particular, green tea catechins are involved in many biological activities such as antioxidation and modulation of various cellular lipid and proteins. Thus, they are beneficial against degenerative diseases, including obesity, cancer, cardiovascular diseases, and various inflammatory diseases. Some reports also suggest that daily consumption of tea catechins may help in controlling type 2 diabetes. However, other studies have reported that chronic consumption of green tea may result in hepatic failure, neuronal damage, and exacerbation of diabetes, suggesting that interindividual variations in the green tea effect are large. This review will focus on the effect of green tea catechins extracted from the plant on type 2 diabetes and obesity, and the possible mechanistic explanation for the experimental results mainly from our laboratory. It is hoped that green tea can be consumed in a suitable manner as a supplement to prevent the development of type 2 diabetes and obesity.
绿茶和咖啡的消费在全球范围内广泛流行。这些饮品含有咖啡因，通过阻断腺苷受体来激活中枢神经系统，并且由于咖啡因的存在，可能会出现成瘾或耐受性。除了这种咖啡因效应外，绿茶和咖啡的消费一直是关于人类健康、疾病和长寿讨论的核心。特别是，绿茶儿茶素参与了许多生物活性，如抗氧化以及对各种细胞脂质和蛋白质的调节。因此，它们对包括肥胖、癌症、心血管疾病和各种炎症性疾病在内的退行性疾病有益。一些报告还表明，每日摄入茶儿茶素可能有助于控制2型糖尿病。然而，其他研究报告称，长期饮用绿茶可能导致肝衰竭、神经损伤和糖尿病恶化，这表明绿茶效应存在很大的个体差异。本综述将聚焦于从植物中提取的绿茶儿茶素对2型糖尿病和肥胖的影响，以及主要来自我们实验室的实验结果的可能机制解释。希望能以适当的方式饮用绿茶作为预防2型糖尿病和肥胖发生的补充剂。
