Campitelli Michael A, Maxwell Colleen J, Giannakeas Vasily, Bell Chaim M, Daneman Nick, Jeffs Lianne, Morris Andrew M, Austin Peter C, Hogan David B, Ko Dennis T, Lapane Kate L, Maclagan Laura C, Seitz Dallas P, Bronskill Susan E
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Schools of Pharmacy and Public Health & Health Systems, University of Waterloo, Waterloo, Ontario, Canada.
J Am Geriatr Soc. 2017 Sep;65(9):2044-2051. doi: 10.1111/jgs.15013. Epub 2017 Aug 9.
To examine the variability of statin use among nursing home residents and prescribing physicians, and to assess statin use by resident frailty.
Population-based, cross-sectional analysis.
All nursing home facilities (N = 631) in Ontario, Canada between April 1, 2013 and March 31, 2014.
All adults aged 66 years and older who received a full clinical assessment while residing in a nursing home facility and their assigned, most responsible, physician.
Statin use on date of clinical assessment. Resident- and physician-level characteristics ascertained through clinical assessment and health administrative data. Resident frailty was derived using a previously validated index.
Among 76,226 nursing home residents assigned to 1,919 physicians, 25,648 (33.6%) were statin users. There were 13,331 (30.1%) statin users among the 44,290 residents categorized as frail. In an adjusted mixed-effects logistic regression model, frail residents (adjusted odds ratio = 0.62, 95% confidence interval 0.58-0.65) were significantly less likely to be statin users compared with non-frail residents. After adjustment for resident characteristics, the intraclass correlation coefficient indicated that between-physician variability accounted for 9.1% of the residual unexplained variation in statin use (P < .001). Among the 894 physicians assigned 20 or more residents, funnel plots confirmed there were more low-outlying (17.4%) and high-outlying (12.0%) prescribers of statins than expected by chance. Physicians who were high-outlying prescribers had higher historical rates of statin prescribing.
Statin prescribing was substantial within nursing homes, even among frail residents. After controlling for resident characteristics, the likelihood of statin prescribing varied significantly across physicians. Further studies are required to evaluate the risks and benefits of statin use, and discontinuation, among nursing home residents to better inform clinical practice in this setting.
研究疗养院居民及开处方医生使用他汀类药物的变异性,并根据居民虚弱程度评估他汀类药物的使用情况。
基于人群的横断面分析。
2013年4月1日至2014年3月31日期间加拿大安大略省的所有疗养院设施(N = 631)。
所有66岁及以上在疗养院接受全面临床评估的成年人及其指定的、最主要负责的医生。
临床评估当日的他汀类药物使用情况。通过临床评估和健康管理数据确定居民和医生层面的特征。使用先前验证的指数得出居民虚弱程度。
在分配给1919名医生的76226名疗养院居民中,25648名(33.6%)是他汀类药物使用者。在分类为虚弱的44290名居民中,有13331名(30.1%)是他汀类药物使用者。在调整后的混合效应逻辑回归模型中,与非虚弱居民相比,虚弱居民(调整后的优势比 = 0.62,95%置信区间0.58 - 0.65)使用他汀类药物的可能性显著降低。在调整居民特征后,组内相关系数表明医生之间的变异性占他汀类药物使用中剩余无法解释变异的9.1%(P <.001)。在分配了20名或更多居民的894名医生中,漏斗图证实他汀类药物的低异常处方者(17.4%)和高异常处方者(12.0%)比偶然预期的更多。高异常处方的医生有更高的他汀类药物处方历史率。
疗养院中他汀类药物的处方量很大,即使在虚弱居民中也是如此。在控制居民特征后,他汀类药物处方的可能性在医生之间有显著差异。需要进一步研究来评估疗养院居民使用和停用他汀类药物的风险和益处,以便更好地为该环境下的临床实践提供信息。