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美国临终疾病护理院居民中他汀类药物使用的地域差异。

Geographic Variation of Statin Use Among US Nursing Home Residents With Life-limiting Illness.

机构信息

Division of Epidemiology, Department of Population and Quantitative Health Sciences.

Clinical and Population Health Research Program, Graduate School of Biomedical Sciences.

出版信息

Med Care. 2021 May 1;59(5):425-436. doi: 10.1097/MLR.0000000000001505.

Abstract

BACKGROUND

Medically compromised nursing home residents continue to be prescribed statins, despite questionable benefits.

OBJECTIVE

To describe regional variation in statin use among residents with life-limiting illness.

RESEARCH DESIGN

Cross-sectional study using 2016 Minimum Data Set 3.0 assessments linked to Medicare administrative data and health service utilization area resource files.

SETTING

Nursing homes (n=14,147) within hospital referral regions (n=306) across the United States.

SUBJECTS

Long-stay residents (aged 65 y and older) with life-limiting illness (eg, serious illness, palliative care, or prognosis <6 mo to live) (n=361,170).

MEASURES

Prevalent statin use was determined by Medicare Part D claims. Stratified by age (65-75, 76 y or older), multilevel logistic models provided odds ratios with 95% confidence intervals.

RESULTS

Statin use was prevalent (age 65-75 y: 46.0%, 76 y or more: 31.6%). For both age groups, nearly all resident-level variables evaluated were associated with any and high-intensity statin use and 3 facility-level variables (ie, higher proportions of Black residents, skilled nursing care provided, and average number of medications per resident) were associated with increased odds of statin use. Although in residents aged 65-75 years, no associations were observed, residents aged 76 years or older located in hospital referral regions (HRRs) with the highest health care utilization had higher odds of statin use than those in nursing homes in HRRs with the lowest health care utilization.

CONCLUSIONS

Our findings suggest extensive geographic variation in US statin prescribing across HRRs, especially for those aged 76 years or older. This variation may reflect clinical uncertainty given the largely absent guidelines for statin use in nursing home residents.

摘要

背景

尽管有疑问的益处,患有医学并发症的疗养院居民仍继续被开他汀类药物。

目的

描述生命有限的疾病患者中他汀类药物使用的区域差异。

研究设计

使用 2016 年最小数据集中的 3.0 评估,将居民的评估与医疗保险管理数据和医疗服务利用区域资源文件进行链接。

地点

美国 306 个医院转诊区(HRR)内的疗养院(n=14147)。

研究对象

患有生命有限疾病(例如严重疾病、姑息治疗或预后<6 个月)的长期居民(年龄≥65 岁)(n=361170)。

措施

通过医疗保险 Part D 理赔确定他汀类药物的普遍使用情况。按年龄(65-75 岁,76 岁或以上)分层,使用多水平逻辑模型提供比值比及其 95%置信区间。

结果

他汀类药物的使用较为普遍(65-75 岁年龄组:46.0%,76 岁或以上年龄组:31.6%)。对于这两个年龄组,评估的几乎所有居民水平变量都与任何和高强度他汀类药物的使用有关,而 3 个设施水平变量(即黑人居民比例较高、提供的熟练护理以及每位居民的平均用药数量)与他汀类药物使用的几率增加有关。尽管在 65-75 岁的居民中没有观察到相关性,但位于医疗保健利用率最高的 HRR 的 76 岁或以上的居民比位于医疗保健利用率最低的 HRR 的疗养院居民使用他汀类药物的几率更高。

结论

我们的研究结果表明,他汀类药物在美国 HRR 之间的处方存在广泛的地理差异,尤其是对于 76 岁及以上的人群。这种差异可能反映了临床的不确定性,因为在疗养院居民中使用他汀类药物的指南基本上不存在。

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