海马区的胆碱能调节与记忆功能。
Cholinergic modulation of the hippocampal region and memory function.
作者信息
Haam Juhee, Yakel Jerrel L
机构信息
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
出版信息
J Neurochem. 2017 Aug;142 Suppl 2(Suppl 2):111-121. doi: 10.1111/jnc.14052.
Abstract
Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging-related dementia, in which the impairment of hippocampus-dependent learning strongly manifests. Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine's modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. In addition, we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
摘要
乙酰胆碱（ACh）在记忆功能中发挥着重要作用，并且与衰老相关的痴呆症有关，在这类痴呆症中，依赖海马体的学习功能受损表现得尤为明显。胆碱能神经元密集地支配着海马体，介导情景记忆和语义记忆的形成。在此，我们将综述乙酰胆碱对记忆功能调节的最新研究发现，特别关注依赖海马体的学习以及相关神经回路。此外，我们还将讨论乙酰胆碱在记忆功能中作用的复杂性，以便更好地理解其在记忆中的生理作用。这是一篇为第十五届国际胆碱能机制研讨会特刊撰写的文章。
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