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尿苷在健康与疾病中的作用。

The Role of Uridine in Health and Disease.

作者信息

Song Congkuan, Liu Zhen-Juan, Xu Bangjun, Zou Rui, Hu Weidong

机构信息

Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Hubei Provincial Clinical Research Center for Cancer, Wuhan, People's Republic of China.

出版信息

J Inflamm Res. 2025 Jul 29;18:10163-10179. doi: 10.2147/JIR.S506308. eCollection 2025.

DOI:10.2147/JIR.S506308
PMID:40761385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318844/
Abstract

Uridine plays a major role as a key biomolecule in health maintenance and disease treatment. Here, we comb and summarize a large amount of data on the important role of uridine in health, disease and treatment in the past 30 years, conduct a comprehensive and in-depth discussion, and give unique insights and overview on the current situation and difficulties of the application of uridine in disease treatment. The review aims to provide new perspectives and implications for uridine research and to promote further application of uridine in the medical field.

摘要

尿苷作为一种关键生物分子，在维持健康和疾病治疗中发挥着重要作用。在此，我们梳理并总结了过去30年里大量关于尿苷在健康、疾病及治疗方面重要作用的数据，进行了全面深入的讨论，并对尿苷在疾病治疗应用中的现状与困难给出了独到见解和概述。本综述旨在为尿苷研究提供新的视角和启示，促进尿苷在医学领域的进一步应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/f27b78e4b8b4/JIR-18-10163-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/36099174473d/JIR-18-10163-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/a168d3976ca9/JIR-18-10163-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/23abadb4f9e8/JIR-18-10163-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/f27b78e4b8b4/JIR-18-10163-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/36099174473d/JIR-18-10163-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/a168d3976ca9/JIR-18-10163-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/23abadb4f9e8/JIR-18-10163-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c74/12318844/f27b78e4b8b4/JIR-18-10163-g0004.jpg

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本文引用的文献

1
Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases.尿苷及其在代谢性疾病、肿瘤和神经退行性疾病中的作用。
Front Physiol. 2024 Feb 29;15:1360891. doi: 10.3389/fphys.2024.1360891. eCollection 2024.
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UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.UPP1 通过诱导免疫抑制微环境促进肺腺癌进展。
Nat Commun. 2024 Feb 8;15(1):1200. doi: 10.1038/s41467-024-45340-w.
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Red Flags in Primary Mitochondrial Diseases: What Should We Recognize?原发性线粒体疾病的“危险信号”：我们应该识别什么？
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Endocrine features of primary mitochondrial diseases.原发性线粒体疾病的内分泌特征。
Curr Opin Endocrinol Diabetes Obes. 2024 Feb 1;31(1):34-42. doi: 10.1097/MED.0000000000000848. Epub 2023 Dec 4.
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Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.巨噬细胞 P2Y6 受体缺失通过磷脂酶 Cβ/储存操纵钙内流/钙网织蛋白/清道夫受体 A 途径限制泡沫细胞形成，从而减轻动脉粥样硬化。
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CDP-choline to promote remyelination in multiple sclerosis: the need for a clinical trial.胞二磷胆碱促进多发性硬化症的髓鞘再生：开展临床试验的必要性。
Neural Regen Res. 2023 Dec;18(12):2599-2605. doi: 10.4103/1673-5374.373671.
7
Uridine-derived ribose fuels glucose-restricted pancreatic cancer.尿苷衍生的核糖为葡萄糖限制的胰腺癌供能。
Nature. 2023 Jun;618(7963):151-158. doi: 10.1038/s41586-023-06073-w. Epub 2023 May 17.
8
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.从尿苷或 RNA 中回收核糖可支持营养有限条件下的糖酵解。
Nat Metab. 2023 May;5(5):765-776. doi: 10.1038/s42255-023-00774-2. Epub 2023 May 17.
9
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.尿苷通过抑制巨噬细胞铁死亡缓解脓毒症诱导的急性肺损伤。
Int J Mol Sci. 2023 Mar 7;24(6):5093. doi: 10.3390/ijms24065093.
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Role of pro-inflammatory interleukins in osteoarthritis: a narrative review.促炎细胞因子在骨关节炎中的作用：叙述性综述。
Connect Tissue Res. 2023 May;64(3):238-247. doi: 10.1080/03008207.2022.2157270. Epub 2022 Dec 21.