早衰和衰老相关疾病的共同分子和细胞机制。
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.
作者信息
Kubben Nard, Misteli Tom
机构信息
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Nat Rev Mol Cell Biol. 2017 Oct;18(10):595-609. doi: 10.1038/nrm.2017.68. Epub 2017 Aug 9.
Abstract
Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of common diseases associated with ageing, including neurological disorders, diabetes, cardiovascular diseases and cancer. Using the rare premature ageing disorder Hutchinson-Gilford progeria syndrome as a paradigm, we discuss here the shared mechanisms between premature ageing and ageing-associated diseases, including defects in genetic, epigenetic and metabolic pathways; mitochondrial and protein homeostasis; cell cycle; and stem cell-regenerative capacity.
摘要
衰老 是 许多 常见 疾病 的 主要 风险 因素。人类 早衰 疾病 是 识别 和 表征 支撑 生理 衰老 的 细胞 机制 的 强大 模型 系统。对 它们 的 研究 还 有助于 更好 地 理解 与 衰老 相关 的 常见 疾病 的 病因、驱动因素 和 潜在 治疗 策略，包括 神经 疾病、糖尿病、心血管 疾病 和 癌症。以 罕见 的 早衰 疾病 哈钦森－吉尔福德 早衰 综合征 为 范例，我们 在此 讨论 早衰 与 衰老 相关 疾病 之间 的 共同 机制，包括 遗传、表观遗传 和 代谢 途径 的 缺陷；线粒体 和 蛋白质 稳态；细胞 周期；以及 干细胞 再生 能力。
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