在中国西部医院的 HIV 感染者中，梅毒、HBV 和 HCV 合并感染的患病率较高，而乙型肝炎有效疫苗接种率较低。
High prevalence of syphilis, HBV, and HCV co-infection, and low rate of effective vaccination against hepatitis B in HIV-infected patients in West China hospital.
机构信息
Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital of Sichuan University, Guo Xue Alley, Chengdu, P. R. China.
出版信息
J Med Virol. 2018 Jan;90(1):101-108. doi: 10.1002/jmv.24912. Epub 2017 Oct 10.
To investigate the epidemiological features and risk factors of HBV, HCV, and syphilis infection among HIV-infected patients in West China Hospital. A retrospective study was conducted with HIV-infected patients from 2014 to 2016 in West China hospital, SCU. Serum makers for HBV, HCV, and syphilis were detected. Among 894 HIV-infected patients, the prevalence of HIV/HBV, HIV/HCV, HIV/syphilis co-infections was 14.4%, 5.7%, and 18.9% respectively. HIV/HBV/HCV, HIV/HCV/syphilis, and HIV/HBV/syphilis triple co-infection was 7 (0.7%), 12(1.3%), 29(3.2%) respectively. The rate of effective vaccination against HBV was only 7.7% in HIV-infected patients. Age (OR = 0.243 95% CI: 0.114 -0.518), ethnicity (OR = 3.654 95% CI: 1.849-7.218) and education level (OR = 0.140 95% CI: 0.033-0.606) are risk factors affecting HIV/HCV co-infection. A high prevalence of HIV/syphilis, HIV/HBV, and HIV/ HCV co-infection can be observed in west China. The rate for HIV-infected patients who were effectively vaccinated against HBV was fewer than 10%.
为了调查中国西部医院 HIV 感染者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和梅毒感染的流行特征和危险因素。本研究采用回顾性研究方法，对 2014 年至 2016 年在四川大学华西医院就诊的 HIV 感染者进行研究。检测血清 HBV、HCV 和梅毒标志物。在 894 例 HIV 感染者中，HIV/HBV、HIV/HCV 和 HIV/梅毒共感染的患病率分别为 14.4%、5.7%和 18.9%。HIV/HBV/HCV、HIV/HCV/梅毒和 HIV/HBV/梅毒三重共感染的比例分别为 0.7%、1.3%和 3.2%。HIV 感染者中 HBV 有效疫苗接种率仅为 7.7%。年龄（OR=0.243 95%CI：0.114-0.518）、民族（OR=3.654 95%CI：1.849-7.218）和受教育程度（OR=0.140 95%CI：0.033-0.606）是影响 HIV/HCV 共感染的危险因素。在中国西部可以观察到 HIV/梅毒、HIV/HBV 和 HIV/HCV 共感染的高患病率。有效接种 HBV 疫苗的 HIV 感染者比例不足 10%。
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