Anaesthetics Department, Royal Sussex County Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Clinical Effectiveness Unit, Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Br J Surg. 2017 Nov;104(12):1686-1694. doi: 10.1002/bjs.10578. Epub 2017 Aug 9.
Early definitive treatment (cholecystectomy or endoscopic sphincterotomy in the same admission or within 2 weeks after discharge) of gallstone disease after a biliary attack of acute pancreatitis is standard of care. This study investigated whether compliance with early definitive treatment for acute gallstone pancreatitis can be used as a care quality indicator for the condition.
A retrospective cohort study was conducted using the Hospital Episode Statistics database. All emergency admissions to National Health Service hospitals in England with a first time diagnosis of acute gallstone pancreatitis in the financial years 2008, 2009 and 2010 were examined. Trends in early definitive treatment between hospital trusts were examined and patient morbidity outcomes were determined.
During the study interval there were 19 510 patients with an overall rate of early definitive treatment at 34·7 (range 9·4-84·7) per cent. In the 1-year follow-up period, 4661 patients (23·9 per cent) had one or more emergency readmissions for complications related to gallstone pancreatitis. Of these, 2692 (57·8 per cent) were readmissions for acute pancreatitis; 911 (33·8 per cent) were within the first 2 weeks of discharge, with the remaining 1781 (66·2 per cent) occurring after the point at which definitive treatment should have been received. Early definitive treatment resulted in a 39 per cent reduction in readmission risk (adjusted risk ratio (RR) 0·61, 95 per cent c.i. 0·58 to 0·65). The risk was further reduced for acute pancreatitis readmissions to 54 per cent in the early definitive treatment group (adjusted RR 0·46, 0·42 to 0·51).
In acute gallstone pancreatitis, compliance with recommended early definitive treatment varied considerably, with associated variation in outcomes. Compliance should be used as a quality indicator to improve care.
急性胰腺炎发作后,对胆石病进行早期确定性治疗(在同一住院期间或出院后 2 周内进行胆囊切除术或内镜括约肌切开术)是标准治疗方法。本研究旨在探讨急性胆石性胰腺炎的早期确定性治疗是否可以作为该疾病的护理质量指标。
采用回顾性队列研究方法,利用医院入院统计数据库,对 2008 年、2009 年和 2010 财政年度英格兰国家卫生服务医院首次诊断为急性胆石性胰腺炎的所有急诊入院患者进行了检查。分析了医院信托之间早期确定性治疗的趋势,并确定了患者的发病结果。
在研究期间,共有 19510 例患者,总体早期确定性治疗率为 34.7%(9.4%84.7%)。在 1 年随访期间,4661 例(23.9%)患者因胆石性胰腺炎相关并发症而有一次或多次急诊再入院。其中,2692 例(57.8%)为急性胰腺炎再入院;911 例(33.8%)发生在出院后 2 周内,其余 1781 例(66.2%)发生在应接受确定性治疗的时间点之后。早期确定性治疗使再入院风险降低了 39%(校正风险比(RR)0.61,95%置信区间(CI)0.580.65)。在早期确定性治疗组中,急性胰腺炎再入院的风险进一步降低了 54%(校正 RR 0.46,0.42~0.51)。
在急性胆石性胰腺炎中,建议的早期确定性治疗的依从性差异很大,其结果也存在差异。应将依从性作为质量指标,以改善护理。