Cortes Vanessa Faria, Taveira Angela, Cruz Helena Medina, Reis Amanda Alves, Cezar Jéssica Silva, Silva Brener Santos, D'Assunção Cintia Feliciano, Lampe Elisabeth, Villar Livia Melo
Universidade Federal de São João del Rei, Laboratório de Bioquímica Celular, São João del Rei, Minas Gerais, Brazil.
Instituto Oswaldo Cruz - FIOCRUZ, Laboratório de Hepatites Virais, Rio de Janeiro, Rio de Janeiro, Brazil.
Rev Inst Med Trop Sao Paulo. 2017;59:e47. doi: 10.1590/S1678-9946201759047. Epub 2017 Aug 3.
Drug users have been reported to have an increased risk for acquisition of viral hepatitis. This study aims to evaluate the prevalence of HBV and HCV infection and usefulness of saliva for HBsAg and anti-HCV detection in alcoholic patients.A total of 90 alcoholic patients were recruited in 2013. HBsAg and anti-HCV were tested in serum and saliva, anti-HBc and anti-HBs were tested in serum using commercial enzyme immunoassays (EIA).Using serum samples, anti-HCV, HBsAg, anti-HBc and anti-HBs prevalences were 5.6%, 0%, 15.7%, and 29.2%. HBsAg detection in saliva showed 100% of specificity and anti-HCV detection demonstrated 100% of sensitivity and 94.7% of specificity. Low prevalence of HBV and high prevalence of anti-HCV were found and reinforced the recommendation of HBV vaccination to avoid the acute and chronic cases and HCV screening in this group to identify cases for antiviral therapy. Saliva samples could be used for anti-HCV detection in this population, what could increase the diagnosis access.
据报道，吸毒者感染病毒性肝炎的风险增加。本研究旨在评估酒精性肝病患者中HBV和HCV感染的患病率以及唾液用于检测HBsAg和抗-HCV的实用性。2013年共招募了90例酒精性肝病患者。采用商业酶免疫分析法（EIA）检测血清和唾液中的HBsAg和抗-HCV，检测血清中的抗-HBc和抗-HBs。使用血清样本，抗-HCV、HBsAg、抗-HBc和抗-HBs的患病率分别为5.6%、0%、15.7%和29.2%。唾液中HBsAg检测的特异性为100%，抗-HCV检测的敏感性为100%，特异性为94.7%。发现HBV患病率低而抗-HCV患病率高，这进一步强化了对该组人群进行HBV疫苗接种以避免急慢性病例以及进行HCV筛查以确定抗病毒治疗病例的建议。唾液样本可用于该人群的抗-HCV检测，这可以增加诊断途径。
