Feitosa Matheus Levi Tajra, Sarmento Carlos Alberto Palmeira, Bocabello Renato Zonzini, Beltrão-Braga Patrícia Cristina Baleeiro, Pignatari Graciela Conceição, Giglio Robson Fortes, Miglino Maria Angelica, Orlandin Jéssica Rodrigues, Ambrósio Carlos Eduardo
Fellow PhD degree, Postgraduate Program in Anatomy in Domestic and Wild Animals, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, Universidade de São Paulo (USP), Brazil. Intellectual and scientific content of the study; conception and design of the study; acquisition, analysis and interpretation of data, manuscript preparation.
Fellow Master degree, Postgraduate Program in Anatomy in Domestic and Wild Animals, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, USP, Sao Paulo-SP, Brazil. Intellectual and scientific content of the study; conception and design of the study; acquisition, analysis and interpretation of data; manuscript preparation.
Acta Cir Bras. 2017 Jul;32(7):540-549. doi: 10.1590/s0102-865020170070000005.
: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs.
: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative.
: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation.
: Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.
研究人未成熟牙髓干细胞治疗犬慢性脊髓损伤的潜力。
将3只患有慢性脊髓损伤的不同品种犬作为动物临床病例。将人未成熟牙髓干细胞在三个点注入脊髓，并在术前和术后通过肢体功能和磁共振成像（MRI）对动物进行评估。
根据奥尔比量表评估，肢体功能有显著改善，尽管MRI提供的成像数据以及临床症状和评估并不支持这一结果。
如果与物理治疗联合使用，人牙髓干细胞疗法在患有慢性脊髓损伤的犬中呈现出有前景的临床结果。
