SMITten for KCNQ Channels.
作者信息
Tzingounis Anastasios V
机构信息
Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.
出版信息
Biophys J. 2017 Aug 8;113(3):503-505. doi: 10.1016/j.bpj.2017.06.056.
Abstract
摘要
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2
XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits.XE991和利诺吡啶是Kv7/KCNQ通道的状态依赖性抑制剂，它们有利于激活单个亚基。
J Pharmacol Exp Ther. 2017 Jul;362(1):177-185. doi: 10.1124/jpet.117.241679. Epub 2017 May 8.
3
KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.KCNQ与溶质载体同向转运体复合物的形成促进离子通道与溶质载体同向转运体之间的相互作用。
FASEB J. 2017 Jul;31(7):2828-2838. doi: 10.1096/fj.201601334R. Epub 2017 Mar 10.
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Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.渗透调节性肌醇转运蛋白SMIT1通过调节磷脂酰肌醇-4,5-二磷酸（PI(4,5)P2）水平来调节电活动。
Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3290-9. doi: 10.1073/pnas.1606348113. Epub 2016 May 23.
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The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels.皮层KCNQ通道的电压激活取决于全局磷脂酰肌醇-4,5-二磷酸（PIP2）水平。
Biophys J. 2016 Mar 8;110(5):1089-98. doi: 10.1016/j.bpj.2016.01.006.
6
Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels.电压依赖性门控：来自KCNQ1通道的新见解。
Biophys J. 2016 Jan 5;110(1):14-25. doi: 10.1016/j.bpj.2015.11.023.
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Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel.结构域间相互作用决定了IKs离子通道的门控、通透、药理学特性及亚基调节。
Elife. 2014 Dec 23;3:e03606. doi: 10.7554/eLife.03606.
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Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.异源 Kv7.2/7.3 通道在新皮层有髓轴突中差异调节动作电位起始和传导。
J Neurosci. 2014 Mar 5;34(10):3719-32. doi: 10.1523/JNEUROSCI.4206-13.2014.
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Ionic permeation and conduction properties of neuronal KCNQ2/KCNQ3 potassium channels.神经元KCNQ2/KCNQ3钾通道的离子渗透与传导特性
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