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用于生物医学应用的电纺聚己内酯-氧化镁-角蛋白基复合纳米纤维的制备与表征

Fabrication and Characterization of Electrospun PCL-MgO-Keratin-Based Composite Nanofibers for Biomedical Applications.

作者信息

Boakye Maame A D, Rijal Nava P, Adhikari Udhab, Bhattarai Narayan

机构信息

Department of Chemical, Biological, and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USA.

NSF-ERC for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, Greensboro, NC 27411, USA.

出版信息

Materials (Basel). 2015 Jul 7;8(7):4080-4095. doi: 10.3390/ma8074080.

DOI:10.3390/ma8074080
PMID:28793426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5455672/
Abstract

Polymeric nanofibers are of great interest in biomedical applications, such as tissue engineering, drug delivery and wound healing, due to their ability to mimic and restore the function of natural extracellular matrix (ECM) found in tissues. Electrospinning has been heavily used to fabricate nanofibers because of its reliability and effectiveness. In our research, we fabricated poly(ε-caprolactone)-(PCL), magnesium oxide-(MgO) and keratin (K)-based composite nanofibers by electrospinning a blend solution of PCL, MgO and/or K. The electrospun nanofibers were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), mechanical tensile testing and inductively-coupled plasma optical emission spectroscopy (ICP-OES). Nanofibers with diameters in the range of 0.2-2.2 µm were produced by using different ratios of PCL/MgO and PCL-K/MgO. These fibers showed a uniform morphology with suitable mechanical properties; ultimate tensile strength up to 3 MPa and Young's modulus 10 MPa. The structural integrity of nanofiber mats was retained in aqueous and phosphate buffer saline (PBS) medium. This study provides a new composite material with structural and material properties suitable for potential application in tissue engineering.

摘要

聚合物纳米纤维因其能够模拟和恢复组织中天然细胞外基质（ECM）的功能，在生物医学应用如组织工程、药物递送和伤口愈合等方面具有极大的吸引力。由于其可靠性和有效性，静电纺丝已被大量用于制造纳米纤维。在我们的研究中，通过静电纺丝PCL、MgO和/或K的混合溶液，制备了聚（ε-己内酯）-（PCL）、氧化镁-（MgO）和角蛋白（K）基复合纳米纤维。通过扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）、机械拉伸测试和电感耦合等离子体发射光谱（ICP-OES）对静电纺丝纳米纤维进行了分析。使用不同比例的PCL/MgO和PCL-K/MgO制备出了直径在0.2-2.2 µm范围内的纳米纤维。这些纤维呈现出均匀的形态，具有合适的机械性能；极限拉伸强度高达3 MPa，杨氏模量为10 MPa。纳米纤维垫的结构完整性在水性和磷酸盐缓冲盐水（PBS）介质中得以保留。本研究提供了一种具有适合组织工程潜在应用的结构和材料性能的新型复合材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/04ec30dd8f40/materials-08-04080-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/26fcc21966d6/materials-08-04080-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/9426a2efc041/materials-08-04080-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/9a8fff683954/materials-08-04080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/844e019612ff/materials-08-04080-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/8753cf7e687d/materials-08-04080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/04ec30dd8f40/materials-08-04080-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/26fcc21966d6/materials-08-04080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/35e72967e96b/materials-08-04080-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/9426a2efc041/materials-08-04080-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/8cf0d72bb268/materials-08-04080-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/9a8fff683954/materials-08-04080-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/844e019612ff/materials-08-04080-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/8753cf7e687d/materials-08-04080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af25/5455672/04ec30dd8f40/materials-08-04080-g008.jpg

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PLoS One. 2013 Jun 14;8(6):e65603. doi: 10.1371/journal.pone.0065603. Print 2013.
3
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RSC Adv. 2021 Jan 26;11(9):4921-4934. doi: 10.1039/d0ra09189h. eCollection 2021 Jan 25.
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9
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