Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Trends Biotechnol. 2010 Apr;28(4):189-97. doi: 10.1016/j.tibtech.2009.12.006. Epub 2010 Jan 29.
Advances in disease treatment and tissue regeneration are buoyed by new, multifaceted materials that emulate and coercively interact with the local microenvironment. Polyblend nanofibers represent an emerging class of biomimetic nanostructures that can act as proxies of the native tissue, while providing topographical and biochemical cues that promote healing. These fibers are prepared with mixtures of synthetically and naturally derived polymers that can behave cooperatively to demonstrate unique combinations of mechanical, biochemical and structural properties. This flexibility has led to the application of polyblend nanofibers in a wide assortment of tissue engineering and drug delivery systems. In this review, we will examine design criteria and properties of polymer-blend nanofibers and their use in tissue engineering and local therapeutic delivery applications.
疾病治疗和组织再生的进展得益于新型多功能材料，这些材料模拟并强制与局部微环境相互作用。多相共混纳米纤维是一类新兴的仿生纳米结构，可以作为天然组织的替代品，同时提供促进愈合的地形和生化线索。这些纤维是用合成和天然来源的聚合物混合物制备的，它们可以协同作用，表现出独特的机械、生化和结构性能组合。这种灵活性导致了多相共混纳米纤维在各种组织工程和药物输送系统中的应用。在这篇综述中，我们将研究聚合物共混纳米纤维的设计标准和性质及其在组织工程和局部治疗药物输送中的应用。
