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基于掺杂抗菌氧化镁和氧化铜纳米颗粒的聚己内酯电纺网的高级面罩过滤器

Advanced Face Mask Filters Based on PCL Electrospun Meshes Dopped with Antimicrobial MgO and CuO Nanoparticles.

作者信息

Ferreira Carolina A M, Guerreiro Sara F C, Valente Joana F A, Patrício Tatiana M F, Alves Nuno, Mateus Artur, Dias Juliana R

机构信息

Centre for Rapid and Sustainable Product Development (CDRSP), Instituto Politécnico de Leiria, 2030-028 Marinha Grande, Portugal.

Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

出版信息

Polymers (Basel). 2022 Aug 16;14(16):3329. doi: 10.3390/polym14163329.

DOI:10.3390/polym14163329
PMID:36015586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9413239/
Abstract

The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) were produced using an electrospinning technique. A morphological analysis of electrospun meshes evaluated the success of nanoparticles' incorporation as well as the average fibers' diameters (481 ± 272 nm). The performance of electrospun nanofibers was also assessed in terms of tensile strength (0.88 ± 0.25 MPa), water vapor permeability (11,178.66 ± 35.78 g·m·day), stability under wet conditions and antibacterial activity according to the standard guidelines. The filters showed structural stability up to 2 h of washing and improved antibacterial activity against () and () for optimized concentrations of MgO and CuO NPs. Overall, electrospun meshes with antibacterial activity were successfully developed for advanced filtering applications.

摘要

由冠状病毒引起的大流行情况清楚地表明，需要有能够保护呼吸道并使传染因子失活的替代物。基于此，采用静电纺丝技术制备了掺杂氧化镁（MgO）和氧化铜（CuO）纳米颗粒（NPs）的聚己内酯（PCL）抗菌面罩过滤器。对静电纺网进行形态分析，评估了纳米颗粒掺入的成功情况以及平均纤维直径（481±272纳米）。还根据标准指南，从拉伸强度（0.88±0.25兆帕）、水蒸气透过率（11,178.66±35.78克·米·天）、潮湿条件下的稳定性和抗菌活性等方面评估了静电纺纳米纤维的性能。对于优化浓度的MgO和CuO NPs，过滤器在洗涤2小时内显示出结构稳定性，并对（）和（）具有增强的抗菌活性。总体而言，成功开发出了具有抗菌活性的静电纺网用于先进的过滤应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/950eb598314e/polymers-14-03329-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/34d11097b919/polymers-14-03329-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/d25f953d542d/polymers-14-03329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/b11d3f8939e4/polymers-14-03329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/e169c185c806/polymers-14-03329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/5a04a0d735f7/polymers-14-03329-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/3535ed004334/polymers-14-03329-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/950eb598314e/polymers-14-03329-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/34d11097b919/polymers-14-03329-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/fcecfe7dd292/polymers-14-03329-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/d25f953d542d/polymers-14-03329-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/b11d3f8939e4/polymers-14-03329-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/e169c185c806/polymers-14-03329-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/5a04a0d735f7/polymers-14-03329-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/3535ed004334/polymers-14-03329-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eda1/9413239/950eb598314e/polymers-14-03329-g008.jpg

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