Spath Sebastian, Drescher Philipp, Seitz Hermann
Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany.
Materials (Basel). 2015 Jul 24;8(8):4720-4732. doi: 10.3390/ma8084720.
3D printing is a promising method for the fabrication of scaffolds in the field of bone tissue engineering. To date, the mechanical strength of 3D printed ceramic scaffolds is not sufficient for a variety of applications in the reconstructive surgery. Mechanical strength is directly in relation with the porosity of the 3D printed scaffolds. The porosity is directly influenced by particle size and particle-size distribution of the raw material. To investigate this impact, a hydroxyapatite granule blend with a wide particle size distribution was fractioned by sieving. The specific fractions and bimodal mixtures of the sieved granule blend were used to 3D print specimens. It has been shown that an optimized arrangement of fractions with large and small particles can provide 3D printed specimens with good mechanical strength due to a higher packing density. An increase of mechanical strength can possibly expand the application area of 3D printed hydroxyapatite scaffolds.
3D打印是骨组织工程领域中一种很有前景的支架制造方法。迄今为止，3D打印陶瓷支架的机械强度不足以满足重建手术中的各种应用。机械强度与3D打印支架的孔隙率直接相关。孔隙率直接受原材料的粒径和粒径分布影响。为了研究这种影响，通过筛分对具有宽粒径分布的羟基磷灰石颗粒混合物进行分级。筛分后的颗粒混合物的特定级分和双峰混合物用于3D打印试样。结果表明，由于较高的堆积密度，大小颗粒的分级优化排列可以为3D打印试样提供良好的机械强度。机械强度的提高可能会扩大3D打印羟基磷灰石支架的应用领域。
