Tang Cheng-Ming, Tian Yi-Hung, Hsu Shan-Hui
Institute of Oral Science, Chung Shan Medical University, Taichung 40201, Taiwan.
Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.
Materials (Basel). 2015 Jul 31;8(8):4895-4911. doi: 10.3390/ma8084895.
Polyvinyl alcohol (PVA) demonstrates chemical stability and biocompatibility and is widely used in biomedical applications. The porous bamboo charcoal has excellent toxin absorptivity and has been used in blood purification. In this study, bamboo charcoal nanoparticles (BCNPs) were acquired with nano-grinding technology. The PVA and PVA/BCNP nanocomposite membranes were prepared and characterized by the tensile test, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray diffraction (XRD). Results showed that the tensile strength and elongation of the swollen PVA membranes containing 1% BCNPs (PB₁) were significantly greater than those of PVA and other PVA/BCNP composite membranes. In addition, the major absorption band of OH stretching in the IR spectra shifted from 3262 cm¹ for PVA membrane containing 1% BCNP to 3244 cm¹ for PVA membrane containing 20% BCNP. This blue shift might be attributed to the interaction between the PVA molecules and BCNPs. Moreover, the intensity of the XRD peaks in PVA was decreased with the increased BCNP content. The bioactivity of the nanocomposites was evaluated by immersion in the simulated body fluid (SBF) for seven days. The mineral deposition on PB₅ was significantly more than that on the other samples. The mineral was identified as hydroxyapatite (HA) by XRD. These data suggest that the bioactivity of the composite hydrogel membranes was associated with the surface distribution of hydrophilic/hydrophobic components. The PVA/BCNP composite hydrogels may have potential applications in alveolar bone regeneration.
聚乙烯醇（PVA）具有化学稳定性和生物相容性，广泛应用于生物医学领域。多孔竹炭具有优异的毒素吸附性，已用于血液净化。在本研究中，采用纳米研磨技术制备了竹炭纳米颗粒（BCNPs）。制备了PVA和PVA/BCNP纳米复合膜，并通过拉伸试验、衰减全反射傅里叶变换红外光谱（ATR-FTIR）和X射线衍射（XRD）对其进行了表征。结果表明，含1% BCNPs（PB₁）的溶胀PVA膜的拉伸强度和伸长率显著高于PVA和其他PVA/BCNP复合膜。此外，红外光谱中OH伸缩振动的主要吸收带从含1% BCNP的PVA膜的3262 cm⁻¹ 移至含20% BCNP的PVA膜的3244 cm⁻¹。这种蓝移可能归因于PVA分子与BCNPs之间的相互作用。此外，PVA中XRD峰的强度随BCNP含量的增加而降低。通过在模拟体液（SBF）中浸泡7天来评估纳米复合材料的生物活性。PB₅上的矿物质沉积明显多于其他样品。通过XRD鉴定该矿物质为羟基磷灰石（HA）。这些数据表明复合水凝胶膜的生物活性与亲水/疏水成分的表面分布有关。PVA/BCNP复合水凝胶可能在牙槽骨再生中具有潜在应用。
