State Key Laboratory of Mould Technology, Institute of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
J Biomater Sci Polym Ed. 2010;21(6-7):863-76. doi: 10.1163/156856209X448084.
The data for long-term drug-delivery systems are scarce compared to the short-term systems because the required research efforts are more time-consuming. In this study, we report a novel cross-linked composite based on poly(vinyl alcohol) (PVA) containing cupric ions for long-term delivery, which is helpful for contraception and trace element balance in the human body. The composition, corrosion products, crystal structure, chemical structure and mechanical stability of the composite, after being immersed in simulated body fluid (SBF) for one year, were studied by X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and mechanical testing. The results show that no other new elements, such as P, Cl and Ca, appear on the surface of the composite and no Cu(2)O was formed after immersion in SBF for one year. The effectiveness of copper can be greatly improved and the side-effects caused by these compounds might also be eliminated. Furthermore, this novel composite exhibits long-term mechanical stability in SBF. The present in vitro long-term data suggest that this novel copper-containing composite may serve as a substitute for conventional materials of copper-containing intrauterine devices (Cu-IUDs) and as a carrier for controlled-release material in a variety of other applications.
与短期给药系统相比，长期药物输送系统的数据较为缺乏，因为所需的研究工作更为耗时。在这项研究中，我们报告了一种基于含有铜离子的聚乙烯醇（PVA）的新型交联复合材料，用于长期给药，这有助于避孕和人体微量元素平衡。通过 X 射线荧光光谱（XRF）、X 射线衍射（XRD）、差示扫描量热法（DSC）、傅里叶变换红外光谱（FT-IR）和力学测试研究了该复合材料在模拟体液（SBF）中浸泡一年后的组成、腐蚀产物、晶体结构、化学结构和力学稳定性。结果表明，在复合材料表面没有出现 P、Cl 和 Ca 等其他新元素，在 SBF 中浸泡一年后也没有形成 Cu2O。铜的有效性可以得到极大提高，这些化合物引起的副作用也可能被消除。此外，这种新型复合材料在 SBF 中表现出长期的力学稳定性。目前的体外长期数据表明，这种新型含铜复合材料可能替代传统的含铜宫内节育器（Cu-IUD）材料，并可作为各种其他应用中控释材料的载体。
