Valdés-Ramírez Gabriela, Windmiller Joshua R, Claussen Jonathan C, Martinez Alexandra G, Kuralay Filiz, Zhou Ming, Zhou Nandi, Polsky Ronen, Miller Philip R, Narayan Roger, Wang Joseph
Department of NanoEngineering, University of California at San Diego, La Jolla, California 92093-0448, USA.
Sens Actuators B Chem. 2012 Jan 3;161(1). doi: 10.1016/j.snb.2011.11.085.
We report on the development of a microneedle-based multiplexed drug delivery actuator that enables the controlled delivery of multiple therapeutic agents. Two individually-addressable channels on a single microneedle array, each paired with its own reservoir and conducting polymer nanoactuator, are used to deliver various permutations of two unique chemical species. Upon application of suitable redox potentials to the selected actuator, the conducting polymer is able to undergo reversible volume changes, thereby serving to release a model chemical agent in a controlled fashion through the corresponding microneedle channels. Time-lapse videos offer direct visualization and characterization of the membrane switching capability and, along with calibration investigations, confirm the ability of the device to alternate the delivery of multiple reagents from individual microneedles of the array with higher precision and temporal resolution than conventional drug delivery actuators. Analytical modeling offers prediction of the volumetric flow rate through a single microneedle and accordingly can be used to assist in the design of subsequent microneedle arrays. The robust solid-state design and lack of mechanical components circumvent reliability issues that challenge fragile conventional microelectromechanical drug delivery devices. This proof-of-concept study demonstrates the potential of the drug delivery actuator system to aid in the rapid administration of multiple therapeutic agents and indicates the potential to counteract diverse biomedical conditions.
我们报告了一种基于微针的多重药物递送致动器的开发，该致动器能够控制多种治疗剂的递送。单个微针阵列上的两个可单独寻址的通道，每个通道都与自己的储液器和导电聚合物纳米致动器配对，用于递送两种独特化学物质的各种组合。在向选定的致动器施加合适的氧化还原电位后，导电聚合物能够发生可逆的体积变化，从而通过相应的微针通道以可控方式释放模型化学剂。延时视频提供了膜切换能力的直接可视化和表征，并且与校准研究一起，证实了该装置能够以比传统药物递送致动器更高的精度和时间分辨率从阵列的单个微针交替递送多种试剂。分析模型可以预测通过单个微针的体积流速，因此可用于辅助后续微针阵列的设计。坚固的固态设计和无机械部件避免了困扰脆弱的传统微机电药物递送装置的可靠性问题。这项概念验证研究证明了药物递送致动器系统在辅助快速施用多种治疗剂方面的潜力，并表明了应对多种生物医学状况的潜力。
