简短通讯：印度和中国原产恒河猴对阴道猴-人免疫缺陷病毒传播的易感性比较作为HIV预防研究模型
Short Communication: Comparative Susceptibility of Rhesus Macaques of Indian and Chinese Origin to Vaginal Simian-Human Immunodeficiency Virus Transmission as Models for HIV Prevention Research.
作者信息
Veazey Ronald S, Ling Binhua
机构信息
1 Tulane National Primate Research Center , Covington, Louisiana.
2 Department of Pathology and Laboratory Medicine, Tulane University School of Medicine , New Orleans, Louisiana.
出版信息
AIDS Res Hum Retroviruses. 2017 Dec;33(12):1199-1201. doi: 10.1089/AID.2017.0173. Epub 2017 Nov 7.
Abstract
Historically, Indian rhesus macaques (iRMs) have been preferred for simian immunodeficiency virus (SIV)/HIV prevention, pathogenesis, and treatment studies, yet their supply is limited. Chinese rhesus macaques (cRMs) are currently more available, yet little is known regarding the relative susceptibility of this subspecies to vaginal transmission of SIV or simian-human immunodeficiency virus (SHIV). In this study, we compared the susceptibility of 40 cRMs and 21 iRMs with a single vaginal challenge with SHIVsf162P. Our results showed that cRMs have comparable primary SHIV infection as iRMs, underscoring their equal importance in studies of HIV transmission and prevention.
摘要
从历史上看，印度恒河猴一直是猿猴免疫缺陷病毒（SIV）/艾滋病毒预防、发病机制及治疗研究的首选对象，但其供应有限。中国恒河猴目前数量更多，但对于该亚种对SIV或猿猴-人类免疫缺陷病毒（SHIV）经阴道传播的相对易感性了解甚少。在本研究中，我们比较了40只中国恒河猴和21只印度恒河猴单次经阴道感染SHIVsf162P后的易感性。我们的结果表明，中国恒河猴与印度恒河猴的初次SHIV感染情况相当，这突出了它们在艾滋病毒传播及预防研究中的同等重要性。
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