Wang Chen, Wang Yan, Kong Desheng, Xin Ruolei, Xu Weisi, Feng Yi, Shao Yiming, Ma Liying
1 State Key Laboratory of Infectious Disease Prevention and Control, Division of Virology and Immunology, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
2 Beijing Center for Diseases Prevention and Control , Beijing, People's Republic of China .
AIDS Res Hum Retroviruses. 2017 Nov;33(11):1175-1179. doi: 10.1089/AID.2017.0143. Epub 2017 Sep 8.
Cocirculation of multiple subtypes in the same population contributes significantly to the emergence of recombinant viruses. BJ2015EU19, a novel CCR5-tropic human immunodeficiency virus (HIV)-1, second-generation recombinant virus, was isolated from a man who has sex with men in Beijing, China. Phylogenetic analysis of the near full-length genome showed that BJ2015EU19 consisted of seven fragments from CRF01_AE and CRF07_BC. There were six recombinant breakpoints in the pol, vpu, env, and nef genes of BJ2015EU19, which were different from the other circulating recombinant forms and unique recombinant forms (URFs). The new emergence of the URF increases the complexity of the HIV epidemic in the Chinese homosexual group, and the ongoing generation of recombinant viruses may provide an important basis for future analysis of the recombination mechanism of HIV-1.
同一人群中多种亚型的共循环对重组病毒的出现有显著贡献。BJ2015EU19是一种新型的CCR5嗜性人类免疫缺陷病毒（HIV）-1第二代重组病毒，从中国北京一名男男性行为者中分离得到。对近全长基因组的系统发育分析表明，BJ2015EU19由来自CRF01_AE和CRF07_BC的七个片段组成。BJ2015EU19的pol、vpu、env和nef基因中有六个重组断点，这些断点与其他循环重组形式和独特重组形式（URF）不同。URF的新出现增加了中国同性恋群体中HIV流行的复杂性，而重组病毒的持续产生可能为未来分析HIV-1的重组机制提供重要依据。
