脂滴生物发生。
Lipid Droplet Biogenesis.
机构信息
Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; email:
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510. doi: 10.1146/annurev-cellbio-100616-060608. Epub 2017 Aug 9.
Abstract
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.
摘要
脂滴（LDs）是普遍存在的细胞器，它们储存中性脂肪以供能量或膜合成，并作为代谢过程的中心。细胞从头生成 LDs，将细胞转化为含有 LDs 的乳液，LDs 构成细胞质中分散的油相。在这里，我们回顾了我们目前对 LD 生物发生的看法。我们提出了一个从 ER 以不同步骤形成 LD 的模型，并强调了控制这一生物物理过程的蛋白质的生物学特性。确定了知识不完善的领域，并确定了与与 LD 生物学改变相关的生理学和疾病的联系。
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本文引用的文献
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Lipid droplet growth: regulation of a dynamic organelle.脂滴生长：一种动态细胞器的调控
Curr Opin Cell Biol. 2017 Aug;47:9-15. doi: 10.1016/j.ceb.2017.02.002. Epub 2017 Feb 21.
2
COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.衣被蛋白I-转运蛋白II激活Rab18并调节其与脂滴的结合。
EMBO J. 2017 Feb 15;36(4):441-457. doi: 10.15252/embj.201694866. Epub 2016 Dec 21.
3
Seipin regulates ER-lipid droplet contacts and cargo delivery.Seipin调节内质网-脂滴接触及货物运输。
EMBO J. 2016 Dec 15;35(24):2699-2716. doi: 10.15252/embj.201695170. Epub 2016 Nov 22.
4
Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.二酰甘油酰基转移酶2将棕色脂肪细胞中的葡萄糖利用与脂肪酸氧化联系起来。
J Lipid Res. 2017 Jan;58(1):15-30. doi: 10.1194/jlr.M068197. Epub 2016 Nov 11.
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SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase.SEIPIN通过调节甘油-3-磷酸酰基转移酶的活性来调控脂滴扩张和脂肪细胞发育。
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