囊性纤维化的进一步连锁数据：犹他州研究
Further linkage data on cystic fibrosis: the Utah Study.
作者信息
White R, Leppert M, O'Connell P, Nakamura Y, Woodward S, Hoff M, Herbst J, Dean M, Vande Woude G, Lathrop G M
出版信息
Am J Hum Genet. 1986 Dec;39(6):694-8.
We reported earlier complete linkage between cystic fibrosis and an RFLP of the met proto-oncogene revealed by the probe pmetH. Another clone, pmetD, detects another polymorphism with the TaqI restriction enzyme. Further linkage studies, now involving 22 families, have confirmed the tight linkage of cystic fibrosis to the MET and D7S8 loci. Significant allelic association was found between CF and allelic series defined by the pmetH probe.
我们之前报道过，囊性纤维化与由探针pmetH揭示的原癌基因met的一个限制性片段长度多态性（RFLP）之间存在完全连锁。另一个克隆pmetD，用TaqI限制酶检测到另一种多态性。现在对22个家系进行的进一步连锁研究，证实了囊性纤维化与MET和D7S8位点之间的紧密连锁。在CF与由pmetH探针定义的等位基因系列之间发现了显著的等位基因关联。
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