Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Korea.
Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Korea.
Sci Rep. 2017 Aug 9;7(1):7664. doi: 10.1038/s41598-017-08272-8.
Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explored. We obtained 196 emotion task functional magnetic resonance imaging (t-fMRI) from the Human Connectome Project database using a sampling scheme similar to a bootstrapping approach. Brain regions were specified by automated anatomical labeling atlas and the brain activity (z-statistics) of each brain region was correlated with body mass index (BMI) values. Regions with significant correlation were identified and the brain activity of the identified regions was correlated with emotion-related clinical scores. Hippocampus, amygdala, and inferior temporal gyrus consistently showed significant correlation between brain activity and BMI and only the brain activity in amygdala consistently showed significant negative correlation with fear-affect score. The brain activity in amygdala derived from t-fMRI might be good neuroimaging biomarker for explaining the relationship between obesity and a negative emotional state.
肥胖是一种严重的医学病症，与糖尿病、高血压和中风等健康问题密切相关。肥胖与负面情绪状态高度相关，但在神经影像学方面，肥胖与情绪状态之间的关系尚未得到充分探讨。我们使用类似于自举法的抽样方案，从人类连接组计划数据库中获得了 196 项情绪任务功能磁共振成像 (t-fMRI)。通过自动解剖学标记图谱指定脑区，将每个脑区的脑活动（z 统计量）与体重指数 (BMI) 值相关联。确定具有显著相关性的区域，并将识别区域的脑活动与与情绪相关的临床评分相关联。海马体、杏仁核和颞下回的脑活动与 BMI 之间始终表现出显著相关性，而只有杏仁核的脑活动与恐惧情绪评分呈显著负相关。t-fMRI 得出的杏仁核脑活动可能是解释肥胖与负面情绪状态之间关系的良好神经影像学生物标志物。
