Hua Wenfeng, Zhang Anqi, Duan Ping, Zhu Jinhong, Zhao Yuan, He Jing, Zhang Zhi
Department of Laboratory Medicine and Central Laboratories, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang.
Onco Targets Ther. 2017 Jul 27;10:3773-3780. doi: 10.2147/OTT.S140424. eCollection 2017.
Studies have shown that single-nucleotide polymorphisms in gene may play important roles in the development of malignant tumor. The association of del1518 polymorphism (rs3730485) in the promoter with cancer susceptibility has been extensively studied; however, the results are contradictory. To quantify the association between this polymorphism and overall cancer risk, we conducted a meta-analysis with 12,905 cases and 10,026 controls from 16 eligible studies retrieved from PubMed, Embase, and Chinese Biomedical (CBM) databases. We assessed the strength of the connection using odds ratios (ORs) and 95% confidence intervals (CIs). In summary, no significant associations were discovered between the del1518 polymorphism and overall cancer risk (Del/Del vs Ins/Ins: OR =1.01, 95% CI =0.90-1.14; Ins/Del vs Ins/Ins: OR =1.03, 95% CI =0.96-1.12; recessive model: OR =0.98, 95% CI =0.90-1.07; dominant model: OR =1.03, 95% CI =0.94-1.12; and Del vs Ins: OR =1.01, 95% CI =0.94-1.07). In the stratified analysis by source of control, quality score, cancer type, and ethnicity, no significant associations were found. Despite some limitations, the current meta-analysis provides solid statistical evidence of lacking association between the del1518 polymorphism and cancer risk.
研究表明，基因中的单核苷酸多态性可能在恶性肿瘤的发生发展中起重要作用。关于该基因启动子区del1518多态性（rs3730485）与癌症易感性的关联已得到广泛研究；然而，结果相互矛盾。为了量化这种多态性与总体癌症风险之间的关联，我们对从PubMed、Embase和中国生物医学文献数据库（CBM）检索到的16项符合条件的研究中的12905例病例和10026例对照进行了荟萃分析。我们使用优势比（OR）和95%置信区间（CI）评估关联强度。总之，未发现del1518多态性与总体癌症风险之间存在显著关联（Del/Del与Ins/Ins比较：OR = 1.01，95%CI = 0.90 - 1.14；Ins/Del与Ins/Ins比较：OR = 1.03，95%CI = 0.96 - 1.12；隐性模型：OR = 0.98，95%CI = 0.90 - 1.07；显性模型：OR = 1.03，95%CI = 0.94 - 1.12；Del与Ins比较：OR = 1.01，95%CI = 0.94 - 1.07）。在按对照来源、质量评分、癌症类型和种族进行的分层分析中，未发现显著关联。尽管存在一些局限性，但当前的荟萃分析提供了确凿的统计证据，表明del1518多态性与癌症风险之间缺乏关联。
