韩国原发性高血压多中心队列研究：高血压靶器官损害韩国登记处（KorHR）的研究设计与中期分析。

A multicenter cohort study of primary hypertension in Korea: study design and interim analysis of the Korean registry of target organ damage in hypertension (KorHR).

作者信息

Choi Suk-Won, Han Seong Woo, Ok Jong Sun, Yoo Byung-Su, Shin Mi-Seung, Park Sung Ha, Ryu Kyu-Hyung

机构信息

Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University, 7 Keunjaebong-Gil, Hwaseong, Gyeonggido 18450 South Korea.

Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea.

出版信息

Clin Hypertens. 2017 Aug 2;23:16. doi: 10.1186/s40885-017-0072-2. eCollection 2017.

DOI:10.1186/s40885-017-0072-2

PMID:28794898

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540578/

Abstract

BACKGROUND

The Korean Registry of Target Organ Damage in Hypertension aims to evaluate the clinical characteristics and prevalence of subclinical target organ damage in Korean hypertensive patients.

METHOD

This is a prospective, observational, multicenter cohort study in which 23 university hospitals participated. Since May 2013, we have enrolled 1,318 consecutive hypertensive patients without known cardiovascular disease who met the following inclusion criteria: 1) age older than 30 years and 2) the first visit to the participating hospitals was within the last 5 years.

RESULTS

The mean age was 52 ± 12 years; 62.1% were male, and 41.3% were incident hypertensives. Patients with diabetes mellitus accounted for 7.8% of the population and 43.8% had hyperlipidemia or were on statins at baseline. The mean office blood pressures were 152 ± 20/96 ± 14 mmHg for incident hypertensive patients and 129 ± 13/78 ± 10 mmHg for patients on treatment. Patients with electrocardiographic and echocardiographic left ventricular hypertrophy accounted for 18.9 and 25.6%, respectively. The mean brachial-ankle pulse wave velocity (PWV) was 1564 ± 293 m/s and 19.5% had PWV values of more than 1750 cm/s. Patients with microalbuminuria and chronic kidney disease accounted for 21 and 4%, respectively. The first prescribed class of antihypertensive medications was angiotensin converting enzyme inhibitors in 2.9%, angiotensin receptor blockers (ARBs) in 57.5%, diuretics in 7.6%, calcium channel blockers (CCBs) in 61.0%, beta blockers in 17.3%, and fixed dose combination pill in 27.8%.

CONCLUSION

Our interim analysis shows that subclinical target organ damage in hypertension is considerably present for incident or treated hypertensive patients. CCBs and ARBs were the most commonly prescribed classes of antihypertensive medications and fixed dose combination pills were actively used in Korea.

TRIAL REGISTRATION

NCT01861080. Registered 16 May 2013.

摘要

背景

韩国高血压靶器官损害登记旨在评估韩国高血压患者亚临床靶器官损害的临床特征和患病率。

方法

这是一项前瞻性、观察性、多中心队列研究，23家大学医院参与其中。自2013年5月起，我们连续纳入了1318例无已知心血管疾病的高血压患者，这些患者符合以下纳入标准：1）年龄大于30岁；2）首次就诊于参与研究的医院是在过去5年内。

结果

平均年龄为52±12岁；62.1%为男性，41.3%为初发高血压患者。糖尿病患者占总人群的7.8%，43.8%的患者在基线时有高脂血症或正在服用他汀类药物。初发高血压患者的平均诊室血压为152±20/96±14 mmHg，接受治疗的患者为129±13/78±10 mmHg。心电图和超声心动图显示左心室肥厚的患者分别占18.9%和25.6%。平均臂踝脉搏波速度（PWV）为1564±293 m/s，19.5%的患者PWV值超过1750 cm/s。微量白蛋白尿和慢性肾脏病患者分别占21%和4%。首次开具的抗高血压药物类别中，血管紧张素转换酶抑制剂占2.9%，血管紧张素受体阻滞剂（ARB）占57.5%，利尿剂占7.6%，钙通道阻滞剂（CCB）占61.0%，β受体阻滞剂占17.3%，固定剂量复方制剂占27.8%。